Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

542 questions · 578 findings · 107 reviews

No studies found 32 · 5.5%GRADE not reported 76 · 13.1%Very low 155 · 26.8%Low 150 · 26%Moderate 144 · 24.9%High 21 · 3.6%

Timing of wound closure (immediate vs delayed)

Deep surgical site infection · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes deep surgical site infection compared with delayed) (very low certainty).

1 finding from 1 review

Timing of wound closure (immediate vs delayed)

Delayed or non‐union (medium term) · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes delayed union or non‐union compared with delayed) (very low certainty).

1 finding from 1 review

Timing of wound closure (immediate vs delayed)

Adverse events ‐ superficial infection · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes adverse events ‐ superficial infection compared with delayed) (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in intraventricular haemorrhage (IVH, all grades) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Periventricular leukomalacia · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in periventricular leukomalacia (PVL) compared with ECC (low certainty).

1 finding from 1 review