Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

116 questions · 117 findings · 11 reviews · ENT

No studies found 44 · 37.6%GRADE not reported 0 · 0%Very low 28 · 23.9%Low 32 · 27.4%Moderate 11 · 9.4%High 2 · 1.7%

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Intervention not reported

Patient‐reported disease‐specific symptom scores Symptom score with scale of 0 to 3 (0 = no symptoms, 3 = severe symptoms)

The intervention showed no clear difference in patient‐reported disease‐specific symptom scores Symptom score with… (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life scores, measured by SF‐36 (range 0 to 100)

The intervention showed no clear difference in health‐related quality of life scores, measured by SF‐36 (range 0 to… (low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis)

The intervention showed no clear difference in endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis) (low certainty).

1 finding from 1 review