Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

217 questions · 227 findings · 49 reviews · Schizophrenia

No studies found 5 · 2.2%GRADE not reported 12 · 5.3%Very low 105 · 46.3%Low 46 · 20.3%Moderate 57 · 25.1%High 2 · 0.9%

Noradrenaline reuptake inhibitors vs placebo

Clinical global response: significant response or improvement in global status (CGI‐S, high = worse) ‐ short term (4 weeks) · adults with schizophrenia

It is very uncertain whether noradrenaline reuptake inhibitors changes clinical global response: significant response or improvement in… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Mental state: specific ‐ negative symptoms ‐ average endpoint score (SANS, high score = poor) medium term ( · People with schizophrenia and schizophrenia‐like disorders
1 finding from 1 review