It is very uncertain whether antibiotics changes failure to induce clinical remission at end of study compared with no treatment (very low certainty).
The review found no eligible studies for this question.
Antibiotics showed no clear difference in serious adverse events compared with placebo (low certainty).
Antibiotics showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
The review found no eligible studies for this question.
Antibiotics probably leads to lower sore throat: day 3 compared with control (moderate certainty).
Antibiotics showed no clear difference in fever: day 3 compared with control (high certainty).
Antibiotics leads to lower headache: day 3 compared with control (high certainty).
Antibiotics probably leads to lower rheumatic fever (within 2 months, clinical diagnosis) compared with control (moderate certainty).
Antibiotics showed no clear difference in glomerulonephritis (within 1 month, clinical diagnosis) compared with control (low certainty).
Antibiotics leads to lower quinsy (within 2 months, clinical diagnosis) compared with control (high certainty).
Antibiotics leads to lower otitis media (within 14 days, clinical diagnosis) compared with control (high certainty).
Antibiotics showed no clear difference in all‐cause mortality at maximum compared with placebo or no intervention (high certainty).
The review found no eligible studies for this question.
Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).
Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).
Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).
Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).