Findings

What do systematic reviews say?

146 questions · 153 findings · 11 reviews · ENT

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No studies found 62 · 40.5%GRADE not reported 1 · 0.7%Very low 58 · 37.9%Low 22 · 14.4%Moderate 8 · 5.2%High 2 · 1.3%

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

Hearing loss · Children with otitis media with effusion

The review found no eligible studies for this question.

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

OME resolution at short‐term · Children with otitis media with effusion

The review found no eligible studies for this question.

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

OME resolution at intermediate‐term · Children with otitis media with effusion

Summary of findings: intranasal steroids plus oral antibiotic showed no clear difference in OME resolution at intermediate‐term compared with control plus antibiotic (moderate certainty).

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
RR 1.26 [0.54, 2.96]
1 study · 59 participants
Moderate

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

OME resolution at long‐term · Children with otitis media with effusion

The review found no eligible studies for this question.

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

Symptom score [3 months] · Children with otitis media with effusion

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
39 participants
Moderate

Summary of findings: intranasal steroids plus oral antibiotic vs control plus antibiotic

Adverse effects [3 months] · Children with otitis media with effusion

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
GRADE not reported

Grommets vs antibiotic prophylaxis

Proportion of patients who have no AOM recurrences at 6 months post‐randomisation

It is very uncertain whether grommets changes proportion of patients who have no AOM recurrences at 6 months… compared with antibiotic prophylaxis (very low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
RR 1.68 [1.07, 2.65]
2 studies · 96 participants
Very low

Grommets vs antibiotic prophylaxis

Total number of AOM recurrences at 6 months post‐randomisation

It is very uncertain whether grommets changes total number of AOM recurrences at 6 months post‐randomisation compared with antibiotic prophylaxis (very low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Very low

Topical quinolone vs quinolones

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

Topical quinolone may leads to higher resolution of ear discharge ‐ 1 to 2 weeks compared with oral quinolone (low certainty).

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
RR 1.48 [1.24, 1.76]
3 studies · 285 participants
Low

Topical quinolone vs intramuscular gentamicin

Health‐related quality of life · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs intramuscular gentamicin

Ear pain (otalgia) or discomfort or local irritation · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs intramuscular gentamicin

Hearing · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs intramuscular gentamicin

Serious complications · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs intramuscular gentamicin

Suspected ototoxicity · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM

It is very uncertain whether topical quinolone changes resolution of ear discharge ‐ 1 to 2 weeks compared with oral amoxicillin‐clavulanic acid combination (very low certainty).

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
RR 2.93 [1.5, 5.72]
1 study · 56 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured after 4 weeks · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Health‐related quality of life · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Ear pain (otalgia) or discomfort or local irritation · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Hearing · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Topical quinolone vs quinolones

Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found