Oral + inhaled dual therapy vs oral monotherapy
Death · bronchiectasis
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Findings
What do systematic reviews say?
119 questions · 125 findings · 20 reviews · Airways
No studies found 22 · 17.6%GRADE not reported 6 · 4.8%Very low 18 · 14.4%Low 29 · 23.2%Moderate 38 · 30.4%High 12 · 9.6%
Oral + inhaled dual therapy vs oral monotherapy
Quality of life · bronchiectasis
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Fluoroquinolones vs amoxicillin
Exacerbations · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polymyxins vs aminoglycosides
Response rate ‐ improvement in sputum purulence · adults with bronchiectasis
It is very uncertain whether polymyxins changes response rate ‐ improvement in sputum purulence compared with aminoglycosides (very low certainty).
1 finding from 1 review
- OR 0.16 [0.01, 3.85]1 study · 20 participantsVery low
Polymyxins vs aminoglycosides
Response rate ‐ P aeruginosa eradication · adults with bronchiectasis
It is very uncertain whether polymyxins changes response rate ‐ P aeruginosa eradication compared with aminoglycosides (very low certainty).
1 finding from 1 review
- OR 1.4 [0.36, 5.35]1 study · 35 participantsVery low
Polymyxins vs aminoglycosides
Deaths · adults with bronchiectasis
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Polymyxins vs aminoglycosides
Quality of life · adults with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Fluoroquinolones vs amoxicillin
Serious adverse events · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
1 finding from 1 review
- no estimate extracted2 studies · 83 participantsLow
Fluoroquinolones vs amoxicillin
Response rate ‐ treatment failure · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
Fluoroquinolones may leads to lower response rate ‐ treatment failure compared with amoxicillin (low certainty).
1 finding from 1 review
- OR 0.07 [0.01, 0.32]2 studies · 83 participantsLow
Fluoroquinolones vs amoxicillin
Response rate ‐ microbiological response · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
Fluoroquinolones may leads to higher response rate ‐ microbiological response compared with amoxicillin (low certainty).
1 finding from 1 review
- Peto OR 20.09 [2.83, 142.59]1 study · 16 participantsLow
Fluoroquinolones vs amoxicillin
Response rate ‐ improvement in sputum purulence (excellent) · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
It is very uncertain whether fluoroquinolones changes response rate ‐ improvement in sputum purulence (excellent) compared with amoxicillin (very low certainty).
1 finding from 1 review
- OR 2.35 [0.96, 5.72]2 studies · 83 participantsVery low
Fluoroquinolones vs amoxicillin
Deaths · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
1 finding from 1 review
- no estimate extracted2 studies · 83 participantsLow
Fluoroquinolones vs amoxicillin
Quality of life · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polymyxins vs aminoglycosides
Exacerbations · adults with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polymyxins vs aminoglycosides
Serious adverse events · adults with bronchiectasis
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Intervention not reported
Exacerbations Number of events · adults and children with purulent bronchiectasis
The intervention probably leads to lower exacerbations Number of events (moderate certainty).
1 finding from 1 review
- Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes onlyOR 0.31 [0.12, 0.52]10 studies · 654 participantsModerate
Intervention not reported
Hospitalisations Number of events · adults and children with purulent bronchiectasis
The intervention showed no clear difference in hospitalisations Number of events (moderate certainty).
1 finding from 1 review
- Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes onlyOR 0.4 [0.14, 1.11]7 studies · 643 participantsModerate
Intervention not reported
Emergence of resistance Number of events · adults and children with purulent bronchiectasis
The intervention probably leads to higher emergence of resistance Number of events (moderate certainty).
1 finding from 1 review
- Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes onlyOR 3.48 [1.2, 10.07]6 studies · 431 participantsModerate
Intervention not reported
St George Respiratory Questionnaire (SGRQ) total Mean and standard deviation. Scale from 0 to 100 · adults and children with purulent bronchiectasis
1 finding from 1 review
- Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 315 participantsLow