Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Target of exercise: hip vs knee exercises

Pain during activity (long‐term) VAS (0 to 10; higher scores mean worse pain) · patients with patellofemoral pain syndrome (symptoms > 1 month (1 study); symptoms > 6 months (1 study))

It is very uncertain whether target of exercise: hip changes pain during activity (long‐term) VAS (0 to 10; higher scores mean… compared with knee exercises (very low certainty).

1 finding from 1 review

Target of exercise: hip vs knee exercises

Functional status, long‐term · patients with patellofemoral pain syndrome (symptoms > 1 month (1 study); symptoms > 6 months (1 study))

It is very uncertain whether target of exercise: hip changes functional ability (long‐term) WOMAC (0 to 96; inverted scores so… compared with knee exercises (very low certainty).

1 finding from 1 review

High‐intensity vs low‐intensity exercise programmes

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with patellofemoral pain syndrome (untreated PFPS of over 2 months in duration)

It is very uncertain whether high‐intensity changes usual pain (long‐term) VAS (0 to 10; higher scores mean worse pain) compared with low‐intensity exercise programmes (very low certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes usual pain (long‐term) VAS (0 to 10; higher scores mean worse pain) compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

High‐intensity vs low‐intensity exercise programmes

Functional ability · patients with patellofemoral pain syndrome (untreated PFPS of over 2 months in duration)

It is very uncertain whether high‐intensity changes functional ability (long‐term) FIQ modified (0 to 16; higher scores… compared with low‐intensity exercise programmes (very low certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Functional ability · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes functional ability (long‐term) Scale (0 to 100; higher scores mean… compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Recovered · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes recovery (long‐term) Number of patients who had recovered or number… compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

Intervention not reported

Change in long‐term disability more than 3 months after the intervention Measure:6MWT · People with multiple sclerosis
1 finding from 1 review

Intervention not reported

Change in long‐term impairments more than 3 months after the intervention Measures: FIS, FSS · People with multiple sclerosis
1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

Mortality within the longest · patients with vitamin K antagonist‐induced bleeding requiring acute intervention

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

1 finding from 1 review