Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride mouthrinse alone; GRADE not reported.

1 finding from 1 review

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.

1 finding from 1 review

Fluoride varnish combined with fluoride toothpaste vs Fluoride varnish

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride varnish alone; GRADE not reported.

1 finding from 1 review

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse, gel or varnish combined with fluoride… showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Severe maternal morbidity and mortality index · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in severe maternal morbidity and mortality index compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pregnancy loss or stillbirth at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pregnancy loss or stillbirth at any gestational age compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Caesarean section · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in caesarean section compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Low birthweight · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in birthweight < 2500 g compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Apgar score less than 7 at 5 minutes · women who are not yet pregnant and women in the early stages of pregnancy

It is very uncertain whether calcium changes apgar < 7 at 5 minutes compared with placebo (offspring outcomes) commencing before or early (very low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Perinatal death, or NICU admission for > 24 hours (or both) · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in perinatal death, or NICU admission for > 24 hours (or both) compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Pregnancy loss, stillbirth or neonatal death before discharge · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in pregnancy loss, stillbirth or NND before discharge compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review

Maternal smoking during pregnancy vs No maternal smoking during pregnancy

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries)

In the USA study, maternal smoking during pregnancy was associated with increased odds of childhood dental caries (OR 1.85, 95% CI 1.38 to 2.49).

15 findings from 1 review
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