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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Pressure‐garment therapy (PGT) plus silicone vs silicone
Pain (POSAS 0–10, higher score = more severe pain) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 159 participantsVery low
Pressure‐garment therapy (PGT) plus silicone vs silicone
Pruritus (POSAS 0–10, higher score = more severe pruritus; TPIS 0–3, higher score = more severe pruritus; VAS 0–10, higher score = more severe pruritus) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted2 studies · 263 participantsVery low
Pressure‐garment therapy (PGT) plus silicone vs silicone
Quality of life (CHU‐9D 0–1, with 1 representing full health; BBSIP 0–5, higher scores = more severe impact) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 159 participantsVery low
Pressure‐garment therapy (PGT) plus silicone vs silicone
Adverse events · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 159 participantsVery low
Pressure‐garment therapy (PGT) plus silicone vs silicone
Adherence · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 159 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Scar improvement (VSS) (0–14, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) vs no treatment/lanolin
Pain (VAS 0–10, higher score = more severe pain) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 104 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Pain (POSAS 0–10, higher score = more severe pain) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Pruritus (POSAS 0–10, higher score = more severe pruritus) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Quality of life (EQ‐5D‐5L 0–1, with 1 representing full health) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Adverse events · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
Pressure‐garment therapy (PGT) plus scar management therapy including silicone vs scar management therapy including silicone
Adherence · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 88 participantsVery low
High‐pressure garment therapy vs low‐pressure garment therapy
Scar improvement (VSS) (0–13, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 58 participantsVery low
High‐pressure garment therapy vs low‐pressure garment therapy
Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
High‐pressure garment therapy vs low‐pressure garment therapy
Pain · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
High‐pressure garment therapy vs low‐pressure garment therapy
Pruritus · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Pressure‐garment therapy (PGT) vs no treatment/lanolin
Pruritus (VAS 0–10, higher score = more severe pruritus) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 104 participantsVery low
High‐pressure garment therapy vs low‐pressure garment therapy
Quality of life · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
High‐pressure garment therapy vs low‐pressure garment therapy
Adverse events · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 60 participantsVery low
High‐pressure garment therapy vs low‐pressure garment therapy
Adherence · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 67 participantsVery low
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Scar improvement (VSS) (0–13, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 60 participantsVery low
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Pain (POSAS 0–10, higher score = more severe pain) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 60 participantsVery low
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Pruritus (POSAS 0–10, higher score = more severe pruritus) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 60 participantsVery low
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Quality of life · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Adverse events · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 60 participantsVery low
Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast (silicone gel bandage))
Adherence · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Pressure‐garment therapy (PGT) vs no treatment/lanolin
Quality of life · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Pressure‐garment therapy (PGT) vs no treatment/lanolin
Adverse events · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 1 participantsUngraded
Pressure‐garment therapy (PGT) vs no treatment/lanolin
Adherence · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extractedNRNo studies
Pressure‐garment therapy (PGT) vs silicone
Scar improvement (VSS) (0–13, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 96 participantsVery low
Pressure‐garment therapy (PGT) vs silicone
Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring
Pressure‐garment therapy for preventing hypertrophic scarring after burn injury (2024) · Cochrane
no estimate extracted1 study · 159 participantsVery low
Intervention NR
Finding 12. Physical activity should form part of a treatment plan for both men and women with bipolar disorder. Messaging from professionals tended to concentrate on the benefits of weight loss but did not promote potential mental health benefits... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted12 participantsModerate
Intervention NR
Finding 13. The enabling role of trained, multidisciplinary professionals was highlighted. Having the right health and social care professionals can deliver a holistic approach to care. Trained mental health professionals involved in physical acti... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted13 participantsModerate
Intervention NR
Finding 14. Finding the right support could facilitate participation and encourage men and women to be active. Having support, whether from professionals or friends and family, was important. · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted14 participantsModerate
Intervention NR
Finding 15. Mood regulation is an important aspect of managing symptoms of bipolar disorder, and monitoring mood and physical activity, including the use of technology, may be helpful for men and women with bipolar disorder. This can be used to he... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted15 participantsModerate
Intervention NR
Finding 16. Accessible, sustainable interventions and finding the right type of exercise were all identified as important. For many women and men with bipolar disorder, the right type of exercise was walking. · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted16 participantsModerate
Intervention NR
Finding 17. Finding balance, rhythm, structure, and establishing a regular physical activity routine was beneficial. Rhythm and routine brought balance and structure for men and women with bipolar disorder. Incorporating regular physical activity ... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted17 participantsModerate
Intervention NR
Finding 18: Appropriate coping strategies may support engagement in physical activity and other health‐promoting behaviours. Negative coping mechanisms or a lack of coping strategies for men and women with bipolar disorder can affect engagement. P... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted18 participantsModerate
Intervention NR
Finding 19: Connecting to nature when undertaking physical activity may convey additional benefits, including increasing the opportunity for social contact, engaging with nature, and reducing stress, that are often associated with spending time ou... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted19 participantsModerate
Intervention NR
Finding 20. There are some considerations for designing interventions that promote physical activity for bipolar disorder. These include sequencing multicomponent lifestyle changes, technology, incentives, and health promotion strategies that are ... · s where they do not wish or feel the need to participate in physical activity.
Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of… (2024) · Cochrane
no estimate extracted20 participantsModerate
Surgery alone vs pharmacological therapy alone
Disease‐related complications · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
no estimate extractedNRNo studies
Surgery alone vs preoperative pharmacological therapy and surgery
Adverse events · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
RR 1.23 [0.7, 2.03]5 studies · 267 participantsVery low
Surgery alone vs preoperative pharmacological therapy and surgery
All‐cause mortality · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
no estimate extractedNRNo studies
Surgery alone vs preoperative pharmacological therapy and surgery
Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
RR 0.48 [0.05, 5.06]1 study · 61 participantsVery low
Surgery alone vs preoperative pharmacological therapy and surgery
Non‐surgical therapy for recurrent or persistent diseaseRadiation therapy and/or pharmacologic therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
RR 1.22 [0.65, 2.28]2 studies · 100 participantsVery low
Surgery alone vs preoperative pharmacological therapy and surgery
Health‐related quality of life · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
no estimate extractedNRNo studies
Surgery alone vs pharmacological therapy alone
Disease recurrence · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
no estimate extractedNRNo studies
Surgery alone vs pharmacological therapy alone
Adverse events · adults with growth‐hormone secreting pituitary adenomas
Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane
RR 0.09 [0.01, 1.47]1 study · 22 participantsVery low