Findings

What do systematic reviews say?

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

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No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Probenecid vs allopurinol

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.25 [0.28, 5.62]
2 studies · 91 participants
Low

Benzbromarone vs allopurinol

Total adverse events · people with chronic gout

Benzbromarone showed no clear difference in total adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 3 [0.64, 14.16]
1 study · 55 participants
Low

Benzbromarone vs allopurinol

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs probenecid

Acute gout attacks · people with chronic gout

Benzbromarone showed no clear difference in acute gout attacks compared with probenecid (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.73 [0.09, 5.83]
2 studies · 129 participants
Low

Benzbromarone vs probenecid

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) · people with chronic gout

Benzbromarone probably leads to higher serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) compared with probenecid (moderate certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.43 [1.02, 2]
1 study · 62 participants
Moderate

Endpoint International Index of Erectile Function (IIEF) total scores (The IIEF is a self‐report measure with 15 questions examining erectile function, orgasmic function, sexual desire, and intercourse satisfaction. Maximum possible score 75) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ question 3: ability to achieve erection (Maximum score 5) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 231 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ intercourse satisfaction (questions 6, 7, 8) (Maximum score 15) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Moderate

Sildenafil vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Sildenafil probably leads to lower clinical Global Impression ‐Sexual Function not "much/very much… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.44 [0.33, 0.58]
2 studies · 187 participants
Moderate

Sildenafil vs placebo

Dropout · people with antidepressant‐induced sexual dysfunction

Sildenafil showed no clear difference in dropouts (People leaving the trial early) compared with placebo (high certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.68 [0.41, 1.14]
4 studies · 353 participants
High

Bupropion vs placebo

Endpoint scale total scores (150 mg twice daily dose) (Scales of sexual functioning. As studies used different scales to assess sexual functioning, differences are expressed as standardised mean differences (SMD)) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 482 participants
Moderate

Bupropion vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Bupropion showed no clear difference in 50% reduction in score on the Arizona Sexual Experiences Scale… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.62 [0.09, 4.41]
2 studies · 71 participants
Moderate

Bupropion vs placebo

Dropout · people with antidepressant‐induced sexual dysfunction

Bupropion showed no clear difference in dropouts (People leaving the trial early) compared with placebo (high certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 1.08 [0.67, 1.72]
5 studies · 579 participants
High

QUETIAPINE vs Typical antipsychotics

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

Quetiapine showed no clear difference in global state No clinical significant response as defined by the… compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.96 [0.75, 1.23]
16 studies · 1607 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Leaving the study early · patients with schizophrenia

Quetiapine showed no clear difference in leaving the study early due to any reason compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.91 [0.81, 1.01]
23 studies · 3576 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1934 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Mental state: 3. Negative symptoms ‐ average endpoint score PANSS negative subscore · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1934 participants
Moderate