Findings

What do systematic reviews say?

1,133 questions · 1,153 findings · 36 reviews · Skin

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No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Radix tripterygium hypoglaucum tablet (THT) vs Tripterygium glucosides tablet (TGT)

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Lin 2005: TGT - menstrual disturbance (6) and leucopenia (1). Tripterygium glucosides are known to be cytotoxic and unsuitable for individuals of child-bearing age.
1 study · 94 participants
GRADE not reported

Ciclosporin rinse vs Placebo (vehicle cream)

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Eisen 1990: no adverse side-effects; transient burning sensation of mucosal surfaces during swishing of medication reported in all participants.
1 study · 8 participants
GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Yoke 2006: no significant adverse events; transient burning sensation upon initial application with both treatments.
1 study · 15 participants
GRADE not reported

Ciclosporin rinse vs Placebo (vehicle cream)

Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus

Ciclosporin rinse led to lower physician Global Assessment (severity of disease) compared with placebo (vehicle); GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -1.40 [-1.86, -0.94]
1 study · 8 participants
GRADE not reported

Fluocinonide in adhesive base vs placebo

Partial response (>33% improvement) · People with erosive oral lichen planus

Fluocinonide in adhesive base showed no clear difference in partial response (>33% improvement) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 3.00 [0.62, 14.62]
1 study · 27 participants
GRADE not reported

Clobetasol propionate ointment vs 5% topical mesalazine gel in adhesive base

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Sardella 1998: no side-effects (there were no reported side-effects with topical mesalazine gel).
1 study · 12 participants
GRADE not reported

Aloe vera gel vs placebo

Participant‐reported pain relief of 50% or greater · People with erosive oral lichen planus

Aloe vera gel led to higher pain (>=50% improvement in symptoms) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 6.16 [2.35, 16.13]
1 study · 45 participants
GRADE not reported

Ciclosporin rinse vs Placebo (vehicle cream)

Pain reduction (participant-reported symptoms) · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
We were unable to extract data on participant-reported symptoms for Eisen 1990 because there was no breakdown of data for the ELP subgroup.
1 study · 8 participants
GRADE not reported

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Partial response (partial or complete response) · People with erosive oral lichen planus

Topical clobetasol propionate 0.025% showed no clear difference in partial response (partial or complete response) compared with topical clobetasol propionate 0.05%; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 1.18 [0.82, 1.70]
1 study · 35 participants
GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Reduction in target/mean lesion size · People with erosive oral lichen planus

Topical tacrolimus 0.1% ointment showed no clear difference in reduction in target/mean lesion size compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD 0.00 [-1.09, 1.10]
1 study · 29 participants
GRADE not reported

Fluocinonide in adhesive base vs placebo

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Voute 1993: no side-effects during the study and follow-up period.
1 study · 27 participants
GRADE not reported

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Carbone 2009: no side-effects.
1 study · 35 participants
GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

Clobetasol-17-propionate 0.025% lipid-loaded microspheres led to lower pain reduction (VAS 0-100) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -18.30 [-28.57, -8.03]
1 study · 45 participants
GRADE not reported