Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Intensive glycaemic control vs conventional glucose control

Progression of retinopathy · persons with type 1 diabetes mellitus

Intensive glucose control probably leads to lower progression of retinopathy compared with conventional glucose control (moderate certainty).

2 findings from 1 review

Intervention not reported

Serum concentrations ‐ aminoglycoside antibiotics: peak concentration · patients with leading serum concentrations within therapeutic range
1 finding from 1 review

Intervention not reported

Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants within therapeutic range ‐ aminoglycoside antibiotics: % of participants with peak concentrations adequate after 2 days · patients with leading serum concentrations within therapeutic range

The intervention probably leads to higher proportion of participants within therapeutic range ‐ aminoglycoside… (moderate certainty).

1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in dystrophinopathies % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Abdominoperineal excision of the rectum rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes abdominoperineal excision of the rectum rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Abdominoperineal excision of rectum rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes abdominoperineal excision of rectum rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Knee length vs compression stockings

Deep vein thrombosis · patients with prevention of deep vein thrombosis1

It is very uncertain whether knee length changes deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan,… compared with thigh length graduated compression stockings (very low certainty).

3 findings from 1 review

Factor Xa inhibitors vs Anticoagulants

Minor bleeding · Anticoagulants in ACS

Factor Xa inhibitors showed no clear difference in minor bleeding at 30 days compared with anticoagulants (high certainty).

3 findings from 1 review