Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,355 questions · 2,459 findings · 279 reviews

No studies found 556 · 22.6%GRADE not reported 490 · 19.9%Very low 593 · 24.1%Low 479 · 19.5%Moderate 243 · 9.9%High 98 · 4%

Any upright vs supine

Trauma to the birth canal that required suturing: third/fourth degree tears · women in the second stage of labour without epidural anaesthesia

It is very uncertain whether any upright changes trauma to the birth canal that required suturing: third/fourth… compared with supine position (very low certainty).

1 finding from 1 review

Ocriplasmin injection vs control

3‐line or greater improvement in best‐corrected visual acuity · people with symptomatic vitreomacular adhesion

Ocriplasmin injection probably leads to higher 3‐line or greater improvement in best‐corrected visual acuity compared with control (moderate certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for ETT exchange (defined as more than one attempt to arrive at the final endotracheal tube size) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for ETT exchange (defined as more than one attempt to arrive at… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for tracheal re‐intubation for postoperative stridor (defined as the need to re‐intubate to assure oxygenation to deal with postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for tracheal re‐intubation for postoperative stridor (defined… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for epinephrine to treat stridor (defined as the need to use epinephrine to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for epinephrine to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for intensive care unit (ICU) admission to treat post extubation stridor (as defined by the trial authors) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for intensive care unit (ICU) admission to treat post… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for corticosteroid to treat stridor (defined as the need to use corticosteroid to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for corticosteroid to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Zinc polycarboxylate cement vs Any other orthodontic band adhesive

Outcome not reported · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…

The review found no eligible studies for this question.

1 finding from 1 review