Cochrane · systematic review · CD011874
Ocriplasmin for symptomatic vitreomacular adhesion
Neffendorf, JE, Kirthi, V, Pringle, E, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 57.1%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ocriplasmin injection compared with control for symptomatic vitreomacular adhesion
Population: people with symptomatic vitreomacular adhesion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete release of vitreous adhesion Ocriplasmin injection vs control | RR 3.46 [2, 6] | NR | High |
Closure of macular hole Ocriplasmin injection vs control | RR 2.87 [1.5, 5.51] | NR | High |
Complete posterior vitreous detachment Ocriplasmin injection vs control | RR 2.94 [1.39, 6.24] | NR | High |
3‐line or greater improvement in best‐corrected visual acuity Ocriplasmin injection vs control | RR 1.95 [1.07, 3.53] | NR | Moderate Downgraded: imprecision |
Requirement for vitrectomy Ocriplasmin injection vs control | RR 0.67 [0.5, 0.91] | NR | Moderate Downgraded: imprecision |
Mean change in validated visual function questionnaire score from baseline Score ranges from 0 to 100, higher scores are better visual function Ocriplasmin injection vs control | no estimate extracted | NR | Moderate Downgraded: imprecision |
Any ocular adverse event Ocriplasmin injection vs control | RR 1.22 [1.09, 1.37] | NR | Moderate Downgraded: imprecision |