Findings

What do systematic reviews say?

4,695 questions · 4,979 findings · 433 reviews

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No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Oral gabapentin vs placebo

Change in disability score · adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Low

Oral gabapentin vs placebo

Muscle strength · adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Oral antibiotics vs placebo

Withdrawals due to adverse events · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 199 participants
Very low

Oral antibiotics vs placebo

Minor adverse events not leading to withdrawal of treatment · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Oral antibiotics vs placebo

Microbiology Emergence of resistant organisms · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 98 participants
Very low

Oral antibiotics vs placebo

Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Moderate

Oral antibiotics vs placebo

No of participants in whom S. aureus was isolated · people with atopic dermatitis

Oral antibiotic showed no clear difference in no of participants in whom S. aureus was isolated compared with placebo (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.76 [0.46, 1.26]
3 studies · 144 participants
Low

Oral antibiotics vs placebo

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with atopic dermatitis

Oral antibiotic showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with placebo (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.8 [0.18, 3.5]
2 studies · 75 participants
Low

Oral antibiotics vs placebo

Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Moderate

Chloral hydrate vs placebo or no intervention

Good or better behaviour · Children and adolescents (0 to 16 years) needing dental treatment

It is very uncertain whether chloral hydrate changes good or better behaviour compared with placebo (including no intervention) (very low certainty).

1 finding from 1 review

Sedation of children undergoing dental treatment 2018 · Cochrane All outcomes
RR 1.33 [0.80, 2.22]
1 study · 60 participants
Very low

Oral gentamicin vs nalidixic acid

Diarrhoea · patients with Shigella dysentery

It is very uncertain whether oral gentamicin changes diarrhoea at compared with nalidixic acid (very low certainty).

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
RR 1.71 [0.98, 2.97]
1 study · 79 participants
Very low

Oral gentamicin vs nalidixic acid

Relapse ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral gentamicin vs nalidixic acid

Serious adverse events ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral gentamicin vs nalidixic acid

Other adverse events ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of treatment for hypoglycaemia during initial hospital stay… compared with placebo (moderate certainty).

1 finding from 1 review

Oral dextrose gel to prevent hypoglycaemia in at‐risk neonates 2023 · Cochrane Headline outcomes only
RR 0.89 [0.79, 1]
2 studies · 2548 participants
Moderate

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Proportion of children with other untreated oral health needs · School children (aged 4 to 15 years), primary and secondary schools in the UK and India

The review found no eligible studies for this question.

1 finding from 1 review

School dental screening programmes for oral health 2022 · Cochrane All outcomes
Proportion of children with other treated/untreated oral health need: Not reported (Summary of findings 1).
0 studies
No studies found

Oral misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · women undergoing first trimester abortion

Oral misoprostol probably leads to higher failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 2.38 [1.46, 3.87]
3 studies · 1704 participants
Moderate
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 3.68 [1.56, 8.71]
2 studies · 216 participants
Low

Oral misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.14 [1.03, 1.26]
2 studies · 1380 participants
Low
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.21 [0.92, 1.61]
2 studies · 216 participants
Low

Oral misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.25 [0.65, 2.39]
1 study · 100 participants
Low

Oral misoprostol vs vaginal misoprostol

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found