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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
3,601 questions in 252 reviews · Pregnancy and Childbirth
current versionsNo studies 726 · 20.2%Ungraded 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Insulin vs anti‐diabetic agent Postnatal weight retention or return to pre‐pregnancy weight ‐ Maternal weight six to eight weeks postpartum ‐ Maternal weight one year postpartum · the treatment of women (maternal outcomes) with gestational diabetes Insulin for the treatment of women with gestational diabetes (2017) · Cochrane | MD 1.6 | 1 study · 167 participants | Low |
Insulin vs anti‐diabetic agent Postnatal depression ‐ not reported · the treatment of women (maternal outcomes) with gestational diabetes Insulin for the treatment of women with gestational diabetes (2017) · Cochrane | no estimate extracted | NR | No studies |
Insulin vs anti‐diabetic agent Induction of labour · the treatment of women (maternal outcomes) with gestational diabetes Insulin for the treatment of women with gestational diabetes (2017) · Cochrane | RR 1.3 | 3 studies · 348 participants | Moderate |
Insulin vs anti‐diabetic agent Large‐for‐gestational age (birthweight > 90th centile) · Infants of women with gestational diabetes. Insulin for the treatment of women with gestational diabetes (2017) · Cochrane | RR 1.01 [0.76, 1.35] | 13 studies · 2352 participants | Moderate |
Antibiotic prophylaxis vs no treatment Incidence of episiotomy wound infection with wound dehiscence · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | RR 0.13 [0.01, 2.28] | 73 participants | Very low |
Antibiotic prophylaxis vs no treatment Incidence of episiotomy wound dehiscence without wound infection · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | RR 0.82 [0.29, 2.34] | 73 participants | Very low |
Antibiotic prophylaxis vs no treatment Incidence of puerperal infection (endometritis) · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | no estimate extracted | 73 participants | Very low |
Antibiotic prophylaxis vs no treatment Incidence of severe maternal infectious morbidity · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Antibiotic prophylaxis vs no treatment Discomfort or pain at episiotomy wound site · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Antibiotic prophylaxis vs no treatment Women's satisfaction with care · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Antibiotic prophylaxis vs no treatment Adverse effects of antibiotics · women with episiotomy repair following vaginal birth Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Routine antibiotic prophylaxis vs no treatment or placebo Incidence of severe maternal infectious morbidity (including septicaemia, septic shock, laparotomy/hysterectomy for infection, maternal intensive care unit admission, or organ failure) · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Routine antibiotic prophylaxis vs no treatment or placebo Endometritis · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | RR 0.28 [0.09, 0.83] | 2 studies · 1364 participants | Very low |
Routine antibiotic prophylaxis vs no treatment or placebo Urinary tract infection · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | RR 0.25 [0.05, 1.19] | 2 studies · 1706 participants | Low |
Routine antibiotic prophylaxis vs no treatment or placebo Wound infection (episiotomy dehiscence) · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | RR 0.78 [0.31, 1.96] | 2 studies · 1364 participants | Very low |
Routine antibiotic prophylaxis vs no treatment or placebo Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | RR 3.03 [0.32, 28.95] | 2 studies · 1706 participants | Very low |
Routine antibiotic prophylaxis vs no treatment or placebo Length of maternal hospital stay · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | no estimate extracted | 1 study · 1291 participants | Very low |
Routine antibiotic prophylaxis vs no treatment or placebo Individual antimicrobial resistance · Women who had normal vaginal births Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Exercise vs control Hypertensive disorders of pregnancy (pre‐eclampsia) · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | RR 0.31 [0.01, 7.09] | 2 studies · 48 participants | Low |
Exercise vs control Mortality and morbidity composite (variously defined by trials, e.g. perinatal or infant death, shoulder dystocia, bone fracture or nerve palsy) · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | RR 0.56 [0.12, 2.61] | 2 studies · 169 participants | Moderate |
Exercise vs control Neonatal hypoglycaemia · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | RR 2 [0.2, 20.04] | 1 study · 34 participants | Low |
Exercise vs control Adiposity ‐ not reported · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Diabetes (type 1, type 2) ‐ not reported · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Neurosensory disability · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Caesarean section · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | RR 0.86 [0.63, 1.16] | 5 studies · 316 participants | Moderate |
Exercise vs control Development of type 2 diabetes ‐ not measured · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Perineal trauma/tearing ‐ not measured · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Postnatal weight retention or return to pre‐pregnancy weight (maternal BMI ( · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | 3 studies · 254 participants | High |
Exercise vs control Postnatal depression ‐ not measured · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Induction of labour · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | RR 1.38 [0.71, 2.68] | 1 study · 40 participants | Low |
Exercise vs control Large‐for‐gestational age ‐ not reported · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | NR | No studies |
Exercise vs control Perinatal mortality (stillbirth and neonatal mortality) · pregnant women with gestational diabetes Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane | no estimate extracted | 1 study · 19 participants | Low |
Healthcare professional‐led breastfeeding education and support vs standard care Initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding Interventions for promoting the initiation of breastfeeding (2016) · Cochrane | RR 1.43 [1.07, 1.92] | 5 studies · 564 participants | Low |
Healthcare professional‐led breastfeeding education and support vs standard care Early initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding Interventions for promoting the initiation of breastfeeding (2016) · Cochrane | no estimate extracted | NR | No studies |
Non‐healthcare professional‐led breastfeeding education and support vs standard care Initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding Interventions for promoting the initiation of breastfeeding (2016) · Cochrane | RR 1.22 [1.06, 1.4] | 8 studies · 5712 participants | Low |
Non‐healthcare professional‐led breastfeeding education and support vs standard care Early initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding Interventions for promoting the initiation of breastfeeding (2016) · Cochrane | RR 1.7 [0.98, 2.95] | 3 studies · 76373 participants | Very low |
Intervention NR Breastfeeding 1 month to 4 months post birth · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | RR 1.24 [1.07, 1.43] | 14 studies · 887 participants | Moderate |
Intervention NR Duration of breastfeeding in days · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | no estimate extracted | 6 studies · 264 participants | Low |
Intervention NR SCRIP score first 6 hours post birth range (0 to 6) at each time point, trials recorded multiple time points** · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | no estimate extracted | 2 studies · 81 participants | Low |
Intervention NR Blood glucose mg/dL at 75 to 180 minutes post birth Thresholds for low glucose vary from 40 mg to 50 mg/dL · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | no estimate extracted | 3 studies · 144 participants | Low |
Intervention NR Infant axillary temperature (°C) · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | no estimate extracted | 6 studies · 558 participants | Low |
Intervention NR Exclusive breastfeeding at hospital discharge to 1 month post birth · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | RR 1.3 [1.12, 1.49] | 6 studies · 711 participants | Moderate |
Intervention NR Exclusive breastfeeding 6 weeks to 6 months post birth · mothers and their healthy newborn infants Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane | RR 1.5 [1.18, 1.9] | 7 studies · 640 participants | Moderate |
Vitamin C and vitamin E vs placebo Total fetal loss · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 1.14 [0.92, 1.4] | 7 studies · 18949 participants | High |
Multivitamin plus iron plus folate vs iron plus folate Early or late miscarriage ‐ Multivitamin + iron + folic acid versus iron + folic acid · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 0.98 [0.94, 1.03] | 10 studies · 94948 participants | Moderate |
Multivitamin plus iron plus folate vs iron plus folate Stillbirth ‐ Multivitamin + iron + folic acid versus iron + folic acid · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 0.92 [0.85, 0.99] | 10 studies · 79851 participants | High |
Multivitamin plus iron plus folate vs iron plus folate Any adverse effects · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | no estimate extracted | NR | No studies |
Vitamin C and vitamin E vs placebo Early or late miscarriage · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 0.9 [0.65, 1.26] | 4 studies · 13346 participants | Moderate |
Vitamin C and vitamin E vs placebo Stillbirth · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 1.31 [0.97, 1.76] | 7 studies · 21442 participants | Moderate |
Vitamin C and vitamin E vs placebo Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women Vitamin supplementation for preventing miscarriage (2016) · Cochrane | RR 1.16 [0.39, 3.41] | 1 study · 739 participants | Moderate |