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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

3,601 questions in 252 reviews · Pregnancy and Childbirth

current versions
No studies 726 · 20.2%Ungraded 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Insulin vs anti‐diabetic agent
Postnatal weight retention or return to pre‐pregnancy weight ‐ Maternal weight six to eight weeks postpartum ‐ Maternal weight one year postpartum · the treatment of women (maternal outcomes) with gestational diabetes
Insulin for the treatment of women with gestational diabetes (2017) · Cochrane
MD 1.61 study · 167 participantsLow
Insulin vs anti‐diabetic agent
Postnatal depression ‐ not reported · the treatment of women (maternal outcomes) with gestational diabetes
Insulin for the treatment of women with gestational diabetes (2017) · Cochrane
no estimate extractedNRNo studies
Insulin vs anti‐diabetic agent
Induction of labour · the treatment of women (maternal outcomes) with gestational diabetes
Insulin for the treatment of women with gestational diabetes (2017) · Cochrane
RR 1.33 studies · 348 participantsModerate
Insulin vs anti‐diabetic agent
Large‐for‐gestational age (birthweight > 90th centile) · Infants of women with gestational diabetes.
Insulin for the treatment of women with gestational diabetes (2017) · Cochrane
RR 1.01 [0.76, 1.35]13 studies · 2352 participantsModerate
Antibiotic prophylaxis vs no treatment
Incidence of episiotomy wound infection with wound dehiscence · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
RR 0.13 [0.01, 2.28]73 participantsVery low
Antibiotic prophylaxis vs no treatment
Incidence of episiotomy wound dehiscence without wound infection · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
RR 0.82 [0.29, 2.34]73 participantsVery low
Antibiotic prophylaxis vs no treatment
Incidence of puerperal infection (endometritis) · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
no estimate extracted73 participantsVery low
Antibiotic prophylaxis vs no treatment
Incidence of severe maternal infectious morbidity · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic prophylaxis vs no treatment
Discomfort or pain at episiotomy wound site · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic prophylaxis vs no treatment
Women's satisfaction with care · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic prophylaxis vs no treatment
Adverse effects of antibiotics · women with episiotomy repair following vaginal birth
Antibiotic prophylaxis for episiotomy repair following vaginal birth (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Routine antibiotic prophylaxis vs no treatment or placebo
Incidence of severe maternal infectious morbidity (including septicaemia, septic shock, laparotomy/hysterectomy for infection, maternal intensive care unit admission, or organ failure) · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Routine antibiotic prophylaxis vs no treatment or placebo
Endometritis · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
RR 0.28 [0.09, 0.83]2 studies · 1364 participantsVery low
Routine antibiotic prophylaxis vs no treatment or placebo
Urinary tract infection · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
RR 0.25 [0.05, 1.19]2 studies · 1706 participantsLow
Routine antibiotic prophylaxis vs no treatment or placebo
Wound infection (episiotomy dehiscence) · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
RR 0.78 [0.31, 1.96]2 studies · 1364 participantsVery low
Routine antibiotic prophylaxis vs no treatment or placebo
Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
RR 3.03 [0.32, 28.95]2 studies · 1706 participantsVery low
Routine antibiotic prophylaxis vs no treatment or placebo
Length of maternal hospital stay · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
no estimate extracted1 study · 1291 participantsVery low
Routine antibiotic prophylaxis vs no treatment or placebo
Individual antimicrobial resistance · Women who had normal vaginal births
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity (2017) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Exercise vs control
Hypertensive disorders of pregnancy (pre‐eclampsia) · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
RR 0.31 [0.01, 7.09]2 studies · 48 participantsLow
Exercise vs control
Mortality and morbidity composite (variously defined by trials, e.g. perinatal or infant death, shoulder dystocia, bone fracture or nerve palsy) · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
RR 0.56 [0.12, 2.61]2 studies · 169 participantsModerate
Exercise vs control
Neonatal hypoglycaemia · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
RR 2 [0.2, 20.04]1 study · 34 participantsLow
Exercise vs control
Adiposity ‐ not reported · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Diabetes (type 1, type 2) ‐ not reported · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Neurosensory disability · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Caesarean section · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
RR 0.86 [0.63, 1.16]5 studies · 316 participantsModerate
Exercise vs control
Development of type 2 diabetes ‐ not measured · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Perineal trauma/tearing ‐ not measured · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Postnatal weight retention or return to pre‐pregnancy weight (maternal BMI ( · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extracted3 studies · 254 participantsHigh
Exercise vs control
Postnatal depression ‐ not measured · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Induction of labour · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
RR 1.38 [0.71, 2.68]1 study · 40 participantsLow
Exercise vs control
Large‐for‐gestational age ‐ not reported · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extractedNRNo studies
Exercise vs control
Perinatal mortality (stillbirth and neonatal mortality) · pregnant women with gestational diabetes
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (2017) · Cochrane
no estimate extracted1 study · 19 participantsLow
Healthcare professional‐led breastfeeding education and support vs standard care
Initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding
Interventions for promoting the initiation of breastfeeding (2016) · Cochrane
RR 1.43 [1.07, 1.92]5 studies · 564 participantsLow
Healthcare professional‐led breastfeeding education and support vs standard care
Early initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding
Interventions for promoting the initiation of breastfeeding (2016) · Cochrane
no estimate extractedNRNo studies
Non‐healthcare professional‐led breastfeeding education and support vs standard care
Initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding
Interventions for promoting the initiation of breastfeeding (2016) · Cochrane
RR 1.22 [1.06, 1.4]8 studies · 5712 participantsLow
Non‐healthcare professional‐led breastfeeding education and support vs standard care
Early initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding
Interventions for promoting the initiation of breastfeeding (2016) · Cochrane
RR 1.7 [0.98, 2.95]3 studies · 76373 participantsVery low
Intervention NR
Breastfeeding 1 month to 4 months post birth · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
RR 1.24 [1.07, 1.43]14 studies · 887 participantsModerate
Intervention NR
Duration of breastfeeding in days · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
no estimate extracted6 studies · 264 participantsLow
Intervention NR
SCRIP score first 6 hours post birth range (0 to 6) at each time point, trials recorded multiple time points** · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
no estimate extracted2 studies · 81 participantsLow
Intervention NR
Blood glucose mg/dL at 75 to 180 minutes post birth Thresholds for low glucose vary from 40 mg to 50 mg/dL · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
no estimate extracted3 studies · 144 participantsLow
Intervention NR
Infant axillary temperature (°C) · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
no estimate extracted6 studies · 558 participantsLow
Intervention NR
Exclusive breastfeeding at hospital discharge to 1 month post birth · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
RR 1.3 [1.12, 1.49]6 studies · 711 participantsModerate
Intervention NR
Exclusive breastfeeding 6 weeks to 6 months post birth · mothers and their healthy newborn infants
Early skin‐to‐skin contact for mothers and their healthy newborn infants (2016) · Cochrane
RR 1.5 [1.18, 1.9]7 studies · 640 participantsModerate
Vitamin C and vitamin E vs placebo
Total fetal loss · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 1.14 [0.92, 1.4]7 studies · 18949 participantsHigh
Multivitamin plus iron plus folate vs iron plus folate
Early or late miscarriage ‐ Multivitamin + iron + folic acid versus iron + folic acid · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 0.98 [0.94, 1.03]10 studies · 94948 participantsModerate
Multivitamin plus iron plus folate vs iron plus folate
Stillbirth ‐ Multivitamin + iron + folic acid versus iron + folic acid · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 0.92 [0.85, 0.99]10 studies · 79851 participantsHigh
Multivitamin plus iron plus folate vs iron plus folate
Any adverse effects · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
no estimate extractedNRNo studies
Vitamin C and vitamin E vs placebo
Early or late miscarriage · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 0.9 [0.65, 1.26]4 studies · 13346 participantsModerate
Vitamin C and vitamin E vs placebo
Stillbirth · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 1.31 [0.97, 1.76]7 studies · 21442 participantsModerate
Vitamin C and vitamin E vs placebo
Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women
Vitamin supplementation for preventing miscarriage (2016) · Cochrane
RR 1.16 [0.39, 3.41]1 study · 739 participantsModerate