Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single 3-arm RCT found no difference in pulpotomy success between MTA and triple antibiotic paste (both 100%; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 TAP teeth): 100% clinical and radiographic success in both MTA and TAP at all follow-ups (1-24 months); no difference between groups; not pooled
1 study · 40 participants
GRADE not reported
All occlusal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled specificity for visual detection of all occlusal lesions was 0.770 (95% CI 0.73 to 0.81).
2 findings from 1 review
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Negative LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced proximal caries was 0.58 (95% CI 0.52 to 0.65) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, pooled specificity of visual detection for all (initial and advanced) occlusal caries was 75.3% (95% CI 70 to 80) (ungraded).
3 findings from 1 review
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Specificity 91.2 [88, 94]
12 studies
GRADE not reported
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
PPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of visual detection for advanced occlusal caries was 77.9% at an assumed prevalence of 22.0% (ungraded).
2 findings from 1 review
PPV 77.9
50 studies
GRADE not reported
PPV 30.6
55 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of radiographic detection for all (initial and advanced) occlusal caries was 91.4% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
NPV 91.4
9 studies
GRADE not reported
NPV 85.0
11 studies
GRADE not reported
Advanced proximal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled sensitivity for radiographic detection of advanced proximal lesions was 0.444 (95% CI 0.38 to 0.51).
8 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Show 5 more findings
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced occlusal caries was 0.53 (95% CI 0.46 to 0.62) (ungraded).
3 findings from 1 review
Negative LR 0.53 [0.46, 0.62]
44 studies
GRADE not reported
Negative LR 0.51 [0.44, 0.6]
38 studies
GRADE not reported
Negative LR 0.54 [0.46, 0.63]
36 studies
GRADE not reported
Sensitivity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for all (initial and advanced) occlusal caries was 49.1% (95% CI 40 to 58) (ungraded).
3 findings from 1 review
Sensitivity 49.1 [40, 58]
12 studies
GRADE not reported
Sensitivity 85.5 [81, 89]
67 studies
GRADE not reported
Sensitivity 85.8 [82, 89]
51 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, the negative lr of radiographic detection for all (initial and advanced) proximal caries was 0.65 (95% CI 0.57 to 0.74) (ungraded).
3 findings from 1 review
Negative LR 0.65 [0.57, 0.74]
31 studies
GRADE not reported
Negative LR 0.65 [0.57, 0.73]
34 studies
GRADE not reported
Negative LR 0.63 [0.56, 0.72]
38 studies
GRADE not reported
Positive LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced proximal caries was 9.82 (95% CI 7.3 to 13.3) (ungraded).
3 findings from 1 review
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Specificity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled specificity of radiographic detection for advanced proximal caries was 95.5% (95% CI 94 to 97) (ungraded).
3 findings from 1 review
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of visual detection for all (initial and advanced) occlusal caries was 0.19 (95% CI 0.15 to 0.25) (ungraded).
3 findings from 1 review
Negative LR 0.19 [0.15, 0.25]
67 studies
GRADE not reported
Negative LR 0.18 [0.14, 0.24]
51 studies
GRADE not reported
Negative LR 0.56 [0.46, 0.68]
12 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) occlusal caries was 1.74 (95% CI 1.3 to 2.4) (ungraded).
3 findings from 1 review
Positive LR 1.74 [1.3, 2.4]
14 studies
GRADE not reported
Positive LR 2.36 [1.4, 4.1]
9 studies
GRADE not reported
Positive LR 2.02 [1.4, 2.9]
11 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for all (initial and advanced) occlusal caries was 0.79 (95% CI 0.65 to 0.96) (ungraded).
3 findings from 1 review
Negative LR 0.79 [0.65, 0.96]
14 studies
GRADE not reported
Negative LR 0.76 [0.58, 0.99]
9 studies
GRADE not reported
Negative LR 0.75 [0.6, 0.94]
11 studies
GRADE not reported
Sensitivity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled sensitivity of radiographic detection for advanced proximal caries was 44.4% (95% CI 38 to 51) (ungraded).
3 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Positive LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of visual detection for advanced occlusal caries was 7.09 (95% CI 5.6 to 8.9) (ungraded).
3 findings from 1 review
Positive LR 7.09 [5.6, 8.9]
94 studies
GRADE not reported
Positive LR 5.0 [4.3, 5.8]
55 studies
GRADE not reported
Positive LR 12.5 [9.2, 16.9]
50 studies
GRADE not reported
Specificity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for advanced occlusal caries was 91.4% (95% CI 88 to 94) (ungraded).
3 findings from 1 review
Specificity 91.4 [88, 94]
36 studies
GRADE not reported
Specificity 89.3 [86, 92]
44 studies
GRADE not reported
Specificity 89.1 [86, 92]
38 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the negative lr of visual detection for advanced occlusal caries was 0.58 (95% CI 0.5 to 0.7) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.5, 0.7]
50 studies
GRADE not reported
Negative LR 0.39 [0.3, 0.5]
94 studies
GRADE not reported
Negative LR 0.29 [0.2, 0.4]
55 studies
GRADE not reported
Oral health-related quality of life · Completely edentulous people
1 finding from 1 review