Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,615 questions · 1,673 findings · 190 reviews · Headline outcomes only

No studies found 278 · 16.6%GRADE not reported 85 · 5.1%Very low 328 · 19.6%Low 460 · 27.5%Moderate 402 · 24%High 120 · 7.2%

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention

Drug or alcohol use, or both following treatment completion ‐ Group‐based intervention As assessed by the ASI, TLFB or CIDI. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention

Treatment completers ‐ Group‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

Non‐trauma‐focused psychological intervention for PTSD and SUD or… showed no clear difference in treatment completers ‐ Group‐based intervention compared with control intervention (low certainty).

1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs psychological interventions

Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs psychological interventions

Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

It is very uncertain whether non‐trauma‐focused psychological intervention for PTSD and SUD or… changes treatment completers compared with active psychological intervention (very low certainty).

1 finding from 1 review

Trauma‐focused psychological intervention vs psychological interventions

Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

Trauma‐focused psychological intervention showed no clear difference in treatment completers compared with active psychological intervention (low certainty).

1 finding from 1 review

Intervention not reported

Subjective knee score ‐ KOOS‐4 score (mean score of 4 components) at 2 years: score from 0 (extreme symptoms) to 100 (no symptoms) · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Treatment failure (graft rupture or ACL reconstruction) at 2 years5 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention may leads to lower treatment failure (graft rupture or ACL reconstruction) at 2 years5 (low certainty).

1 finding from 1 review

Intervention not reported

Treatment failure (meniscal surgery) at 5 years5,7 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in treatment failure (meniscal surgery) at 5 years5,7 (low certainty).

1 finding from 1 review

Intervention not reported

General health‐related quality of life: SF‐36 physical component score (range 0 to 100; higher score = better health state) at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Return to activity or level of sport at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in return to activity or level of sport at 2 years (low certainty).

1 finding from 1 review