Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Intervention not reported

Non‐fatal myocardial infarction Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower non‐fatal myocardial infarction Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Rehospitalisation due to heart failure Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention showed no clear difference in rehospitalisation due to heart failure Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Composite MACE Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention showed no clear difference in composite MACE Long‐term (low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Serious adverse events "Defined as events that result in death, hospitalization, prolongation of hospitalization, or are life threatening (based on the judgment of the study physician)" (Quinn 2010) · Apathy in people with mild‐to‐moderate Alzheimer's disease

Omega‐3 PUFA supplements showed no clear difference in serious adverse events "Defined as events that result in death,… compared with placebo (high certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Function (all scores/instruments): long term Scale from: 0 to 100; higher scores = better function. · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes function (all scores/instruments): long term Scale from: 0 to 100;… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

QoL · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes quality of life: long‐term KOOS QOL score. Scale 0 to 100; higher… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Failure of treatment and adverse effects: long‐term Participants with surgery and symptom recurrence · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes failure of treatment and adverse effects: long‐term Participants… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Pain North Americal Spine Society pain scores. Scale from: 0 to 100 (higher scores indicate less pain). · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes pain: long‐term KOOS Pain score. Scale 0 to 100; higher scores =… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Activity: long term (5 or more years · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes activity: long term (5 or more years compared with microfracture (very low certainty).

1 finding from 1 review