Cochrane · systematic review · CD009002
Omega‐3 fatty acids for the treatment of dementia
Burckhardt, M, Herke, M, Wustmann, T, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
11
No studies
1
Included studies
NR
No studies 1 · 8.3%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 25%High 8 · 66.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Omega‐3 PUFA supplements compared to placebo for people with mild to moderate Alzheimer's disease
Population: people with mild to moderate Alzheimer's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any adverse event (combined: diarrhoea, urinary tract infection, falls, dizziness, agitations) Omega‐3 PUFA supplements vs placebo | RR 1.02 [0.95, 1.1] | 1 study · 402 participants | Moderate Downgraded: risk of bias |
Serious adverse events "Defined as events that result in death, hospitalization, prolongation of hospitalization, or are life threatening (based on the judgment of the study physician)" (Quinn 2010) Omega‐3 PUFA supplements vs placebo | RR 1.05 [0.78, 1.41] | 1 study · 402 participants | High |
QoL Omega‐3 PUFA supplements vs placebo | no estimate extracted | 1 study · 269 participants | Moderate Downgraded: risk of bias, imprecision |
QoL Omega‐3 PUFA supplements vs placebo | no estimate extracted | 1 study · 332 participants | High |
Mental health (depression) Omega‐3 PUFA supplements vs placebo | no estimate extracted | 1 study · 178 participants | High |
Mental health Omega‐3 PUFA supplements vs placebo | no estimate extracted | 2 studies · 543 participants | High |
Global cognitive function Omega‐3 PUFA supplements vs placebo | no estimate extracted | 3 studies · 566 participants | High |
Global cognitive function Omega‐3 PUFA supplements vs placebo | no estimate extracted | 2 studies · 202 participants | High |
IADL Omega‐3 PUFA supplements vs placebo | no estimate extracted | 1 study · 22 participants | Moderate Downgraded: risk of bias, imprecision |
ADL Omega‐3 PUFA supplements vs placebo | no estimate extracted | 2 studies · 544 participants | High |
Overall dementia severity (cognition and function combined) Omega‐3 PUFA supplements vs placebo | no estimate extracted | 2 studies · 542 participants | High |
Memory ‐ not measured Omega‐3 PUFA supplements vs placebo | no estimate extracted | NR | No studies |