Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,247 questions · 1,321 findings · 334 reviews

No studies found 73 · 5.5%GRADE not reported 31 · 2.3%Very low 500 · 37.9%Low 406 · 30.7%Moderate 247 · 18.7%High 64 · 4.8%

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

Leaving the study early (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · people with the acute phase of schizophrenia

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes leaving the study early (2‐10 weeks) vs. standard higher dose (>… compared with OTHER DOSES (very low certainty).

1 finding from 1 review

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

Global state: No clinically significant response (as defined by the original studies) · people with the acute phase of schizophrenia

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes global state: 1. No clinically significant response in global state… compared with OTHER DOSES (very low certainty).

1 finding from 1 review

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

Adverse effects: 1. Clinically significant extrapyramidal side effects (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · people with the acute phase of schizophrenia

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes adverse effects: 1. Clinically significant extrapyramidal side… compared with OTHER DOSES (very low certainty).

1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Health related quality of life measures and functional measures with validated instruments (WOMAC, range 0‐100, higher scores indicate worse pain, stiffness and functional limitations) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Posterior cruciate ligament retention vs posterior stabilised sacrifice

Health related quality of life measures and functional measures with validated instruments (WOMAC, range 0‐100, higher scores indicate worse pain, stiffness and functional limitations) · Patients receiving total knee arthroplasty with or without posterior stabilised design for the treatment of osteoarthritis
1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (all types of arthroplasty designs)

Health related quality of life measures and functional measures with validated instruments (WOMAC, range 0‐100, higher scores indicate worse pain, stiffness and functional limitations) · Patients receiving total knee arthroplasty with or without posterior stabilised design for the treatment of osteoarthritis
1 finding from 1 review

Intervention not reported

Upper extremity maximum voluntary isometric contraction score at 3 months Quantitative Muscle Assessment (QMA) system. Data were normalized, summed and averaged to yield an U/E megascore (higher is better). · people with amyotrophic lateral sclerosis or motor neuron disease
1 finding from 1 review