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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,653 questions in 194 reviews · Gynaecology and Fertility
current versionsNo studies 531 · 20%Ungraded 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GnRHa depot vs GnRHa daily injection Live birth/ongoing pregnancy rate per woman Delivery of one or more living infants/pregnancy beyond 12 weeks of gestation · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | OR 0.95 [0.7, 1.31] | 7 studies · 873 participants | Low |
Different doses of GnRHa depot vs GnRHa daily injection Number of days of gonadotrophin treatment ‐ half dose · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 4 studies · 507 participants | Low |
Different doses of GnRHa depot vs GnRHa daily injection Number of days of gonadotrophin treatment ‐ full dose · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 6 studies · 526 participants | Low |
GnRHa depot vs GnRHa daily injection Clinical pregnancy rate per woman Identified by the presence of a gestational sac on ultrasonography or histopathological confirmation of trophoblast tissue · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | OR 0.96 [0.75, 1.23] | 11 studies · 1259 participants | Moderate |
GnRHa depot vs GnRHa daily injection OHSS incidence rates · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | OR 0.84 [0.29, 2.42] | 5 studies · 570 participants | Low |
GnRHa depot vs GnRHa daily injection Miscarriage rates · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | OR 1.16 [0.7, 1.94] | 9 studies · 512 participants | Low |
GnRHa depot vs GnRHa daily injection Number of oocytes retrieved · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 11 studies · 1142 participants | Low |
GnRHa depot vs GnRHa daily injection Multiple pregnancy rates · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | OR 1.1 [0.49, 2.46] | 4 studies · 132 participants | Low |
GnRHa depot vs GnRHa daily injection Number of gonadotropin (FSH) units employed · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 11 studies · 1043 participants | Low |
Different doses of GnRHa depot vs GnRHa daily injection Number of gonadotrophin (FSH) units employed ‐ half dose · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 5 studies · 616 participants | Very low |
Different doses of GnRHa depot vs GnRHa daily injection Number of gonadotrophin (FSH) units employed ‐ full dose · patients with pituitary down regulation in assisted reproduction cycles Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down… (2013) · Cochrane | no estimate extracted | 6 studies · 527 participants | Low |
Gonadotrophins vs placebo/no treatment Live birth rate per couple randomly assigned · Men with idiopathic male factor subfertility Gonadotrophins for idiopathic male factor subfertility (2013) · Cochrane | OR 9.31 [1.17, 73.75] | 1 study · 30 participants | Very low |
Gonadotrophins vs placebo/no treatment Spontaneous pregnancy rate per couple randomly assigned · Men with idiopathic male factor subfertility Gonadotrophins for idiopathic male factor subfertility (2013) · Cochrane | OR 4.94 [2.13, 11.44] | 5 studies · 412 participants | Moderate |
Herbal preparations vs placebo Change in fibroid related symptoms · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | No studies |
Herbal preparations plus medication vs medication Average volume of total multiple fibroids (cm3) · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations plus medication vs medication Average size of uterus (cm3) · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations vs placebo Adverse events · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | No studies |
Herbal preparations vs medication Change in fibroid related symptoms · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | No studies |
Herbal preparations vs medication Adverse events · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations vs medication Average volume of fibroids (cm3) · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations vs medication Average size of uterus (cm3) · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations plus medication vs medication Change in fibroid related symptoms · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | No studies |
Herbal preparations plus medication vs medication Adverse events · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Herbal preparations plus medication vs medication Average volume of maximum fibroids (cm3) · Women with uterine fibroids Herbal preparations for uterine fibroids (2013) · Cochrane | no estimate extracted | NR | Low |
Acupuncture around the time of oocyte retrieval vs control (sham, placebo, no acupuncture) Live birth rate · women undergoing ART Acupuncture and assisted reproductive technology (2013) · Cochrane | OR 0.87 [0.59, 1.29] | 2 studies · 464 participants | Low |
Acupuncture on the day of ET vs control Live birth rate · women undergoing ART Acupuncture and assisted reproductive technology (2013) · Cochrane | OR 1.22 [0.87, 1.7] | 8 studies · 2505 participants | Low |
Acupuncture vs sham acupuncture Hot flush frequency (number/day) · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 8 studies · 414 participants | Low |
Acupuncture vs sham acupuncture Hot flush severity · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 6 studies · 297 participants | Very low |
Acupuncture vs hormone therapy Hot flush frequency (number/day) · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 3 studies · 114 participants | Low |
Acupuncture vs hormone therapy Hot flush severity · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 2 studies · 84 participants | Low |
Electroacupuncture vs relaxation Hot flush frequency (number/day) · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 1 study · 38 participants | Very low |
Electroacupuncture vs relaxation Hot flush severity · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 1 study · 38 participants | Very low |
Acupuncture vs waitlist or no intervention Change in frequency of hot flushes from baseline to end of study · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 3 studies · 463 participants | Low |
Acupuncture vs waitlist or no intervention Change in hot flush severity from baseline to end of study · women with menopausal hot flushes Acupuncture for menopausal hot flushes (2013) · Cochrane | no estimate extracted | 3 studies · 463 participants | Low |
Brief co‐incubation vs standard insemination Ongoing pregnancy per randomized woman · patients with in vitro fertilization techniques Brief co‐incubation of sperm and oocytes for in vitro fertilization techniques (2013) · Cochrane | OR 2.42 [1.55, 3.77] | 2 studies · 426 participants | Low |
Brief co‐incubation vs standard insemination Clinical pregnancy rate per randomized woman · patients with in vitro fertilization techniques Brief co‐incubation of sperm and oocytes for in vitro fertilization techniques (2013) · Cochrane | OR 2.36 [1.45, 3.85] | 3 studies · 372 participants | Low |
Brief co‐incubation vs standard insemination Miscarriage rate per randomized woman · patients with in vitro fertilization techniques Brief co‐incubation of sperm and oocytes for in vitro fertilization techniques (2013) · Cochrane | OR 1.98 [0.35, 11.09] | 1 study · 167 participants | Low |
Intervention NR Live birth rate per woman · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | OR 1.77 [1.07, 2.9] | 3 studies · 386 participants | Very low |
Intervention NR Clinical pregnancy rate per woman · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | OR 1.61 [1.03, 2.53] | 3 studies · 386 participants | Low |
Intervention NR Adverse effects · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | no estimate extracted | 5 participants | Ungraded |
Intervention NR Live birth rate per woman · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | OR 1.85 [0.8, 4.24] | 3 studies · 386 participants | Very low |
Intervention NR Clinical pregnancy rate per woman · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | OR 1.66 [0.94, 2.9] | 3 studies · 386 participants | Low |
Intervention NR Adverse effects · Subfertile women Heparin for assisted reproduction (2013) · Cochrane | no estimate extracted | 5 participants | Ungraded |
Low‐dose hCG vs FSH throughout the COH Live birth · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | RR 1.56 [0.75, 3.25] | 2 studies · 130 participants | Very low |
Low‐dose hCG vs FSH throughout the COH OHSS · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | OR 0.3 [0.06, 1.59] | 5 studies · 351 participants | Very low |
Low‐dose hCG vs FSH throughout the COH Ongoing pregnancy · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | RR 1.17 [0.83, 1.64] | 3 studies · 252 participants | Low |
Low‐dose hCG vs FSH throughout the COH Clinical pregnancy · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | RR 1.19 [0.92, 1.55] | 5 studies · 351 participants | Low |
Low‐dose hCG vs FSH throughout the COH Miscarriage · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | RR 1.08 [0.5, 2.31] | 4 studies · 127 participants | Very low |
Low‐dose hCG vs FSH throughout the COH Total dose of FSH · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | no estimate extracted | 5 studies · 333 participants | Moderate |
Low‐dose hCG vs FSH throughout the COH Oocytes retrieved · women undergoing assisted reproductive techniques FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive… (2013) · Cochrane | no estimate extracted | 5 studies · 333 participants | Moderate |