Findings

What do systematic reviews say?

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Intervention not reported

Low‐dose atropine (< 0.1%) · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 249 participants
Low

Intervention not reported

Low‐dose atropine (< 0.1%) · children with progressive myopia (36 studies, 6263 participants) in the analysis Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 497 participants
Very low

Intervention not reported

Low‐dose atropine (< 0.1%) · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 497 participants
Very low

Intervention not reported

Low‐dose atropine (< 0.1%) · children with progressive myopia (21 studies, 4169 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 249 participants
Low

GnRHa treatment vs intra‐ uterine progestogen device

No studies included with only low risk of bias · patients with pain associated with endometriosis

The review found no eligible studies for this question.

1 finding from 1 review

Gonadotropin‐releasing hormone analogues for endometriosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo + standard care

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Disease activity · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 100 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Pain (SF‐36 Bodily Pain domain, score 0‐100, lower scores indicate less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 119 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Disease activity · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 184 participants
Moderate

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 121 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo + standard care

Pain (SF‐36 Bodily Pain domain, score 0‐100, lower scores indicate less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 104 participants
Low

Intervention not reported

Mean postoperative BCVA (lower is better) · people with large macular hole

1 finding from 1 review

Pars plana vitrectomy with internal limiting membrane flap versus pars plana vitrectomy with conventional internal… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

Episodes of bradycardia · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer, occurring during the procedure · Procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autoinflation vs no treatment

Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)

1 finding from 1 review

Autoinflation for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intranasal steroid spray vs placebo

Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)

1 finding from 1 review

Topical and oral steroids for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Oral steroids vs placebo

Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)

1 finding from 1 review

Topical and oral steroids for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: cognitive delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.17 [0.02, 1.37]
Studies not reported
Very low