Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,511 questions · 2,668 findings · 290 reviews

No studies found 743 · 27.8%GRADE not reported 329 · 12.3%Very low 775 · 29%Low 484 · 18.1%Moderate 279 · 10.5%High 58 · 2.2%

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Overall survival · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher overall survival compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Clinical progression · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher clinical progression compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Treatment failure · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher treatment failure compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Breast pain · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher breast pain compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Gynaecomastia · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher gynaecomastia compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Hot flashes · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to lower hot flashes compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review