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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
473 questions in 36 reviews · HIV/AIDS
current versionsNo studies 38 · 8%Ungraded 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Depressive symptoms Beck Depression Inventory Score · People living with HIV infection Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection (2013) · Cochrane | no estimate extracted | 3 studies · 447 participants | Low |
Intervention NR Death or lost to care · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.46 [0.29, 0.71] | 4 studies · 39090 participants | Moderate |
Intervention NR Lost to care · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.55 [0.45, 0.69] | 4 studies · 39090 participants | Low |
Intervention NR Death · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.34 [0.13, 0.87] | 4 studies · 39090 participants | Low |
Intervention NR Death or lost to care · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.7 [0.47, 1.02] | 4 studies · 56360 participants | Very low |
Intervention NR Lost to care · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.3 [0.17, 0.54] | 4 studies · 56360 participants | Moderate |
Intervention NR Death · HIV infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 1.1 [0.63, 1.92] | 4 studies · 55099 participants | Very low |
Intervention NR Death or lost to care · HIV‐infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.95 [0.62, 1.46] | 2 studies · 709 participants | Moderate |
Intervention NR Lost to care · HIV‐infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 0.81 [0.3, 2.21] | 2 studies · 709 participants | Moderate |
Intervention NR Death · HIV‐infected patients Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane | RR 1.03 [0.64, 1.65] | 2 studies · 709 participants | Moderate |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Death · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 3 [0.12, 73.06] | 2 studies · 343 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 0.96 [0.06, 14.87] | 2 studies · 122 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | OR 0.64 [0.24, 1.75] | 1 study · 94 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 1.11 [0.86, 1.43] | 1 study · 67 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART Mean weight gain per year in kg · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 94 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART Mean height gain per year in cm · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 94 participants | Very low |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART Mean standardized score on Beery VMI at 144 weeks · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 82 participants | Very low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 1.5 [0.25, 8.85] | 2 studies · 343 participants | Very low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | OR 0.7 [0.39, 1.24] | 2 studies · 343 participants | Very low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 0.96 [0.84, 1.09] | 2 studies · 238 participants | Low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Weight gain per year in kg · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 300 participants | Low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Height gain per year in cm · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 300 participants | Low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Standardized score on Beery VMI at 144 weeks · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | 1 study · 272 participants | Low |
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Patient or population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)Settings: Thailand and CambodiaIntervention: IMMEDIATE initiation of cARTComparison: DEFERRED initiation of cART · HIV‐positive, treatment‐naive children aged one to 12 years old Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | no estimate extracted | NR | No studies |
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old) Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane | RR 2.88 [0.12, 68.88] | 2 studies · 122 participants | Very low |
Intervention NR All‐cause mortality Death reports · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.55 [0.37, 0.82] | 3 studies · 262 participants | Moderate |
Intervention NR All clinic visits ‐ URI · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.75 [0.55, 1.03] | 1 study · 854 participants | Moderate |
Intervention NR All clinic visits ‐ pneumonia · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.89 [0.76, 1.04] | 1 study · 854 participants | Moderate |
Intervention NR All clinic visits ‐ ear infection · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.78 [0.55, 1.11] | 1 study · 854 participants | Moderate |
Intervention NR Mortality at 12 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.88 [0.52, 1.49] | 1 study · 847 participants | Moderate |
Intervention NR CD4 count · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 399 participants | Moderate |
Intervention NR Duration of hospitalisation ‐ All admissions · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 106 participants | Moderate |
Intervention NR Change in appetite at 6 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 99 participants | Moderate |
Intervention NR Anthropometric Z scores ‐ WAZ at 6 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 99 participants | Moderate |
Intervention NR Anthropometric Z scores ‐ HAZ at 6 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 99 participants | Moderate |
Intervention NR Anthropometric Z scores ‐ WHZ at 6 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 99 participants | Moderate |
Intervention NR Child growth at 12 months ‐ Wasting Anthropometric measurements at monthly clinic visits · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.25 [0.06, 1.05] | 1 study · 41 participants | Low |
Intervention NR Child growth at 12 months ‐ Stunting Anthropometric measurements at monthly clinic visits · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.67 [0.34, 1.32] | 1 study · 29 participants | Low |
Intervention NR CD4 counts at 12 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 56 participants | Low |
Intervention NR Viral load at 12 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 56 participants | Low |
Intervention NR Viral load at 9 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 85 participants | Moderate |
Intervention NR Mortality at 9 months Hospital records and verbal autopsies · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.31 [0.07, 1.42] | 1 study · 96 participants | Low |
Intervention NR CD4 % at 9 months · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | no estimate extracted | 1 study · 85 participants | Moderate |
Intervention NR All clinic visits ‐ watery diarrhoea · Children with HIV infection Micronutrient supplementation for children with HIV infection (2013) · Cochrane | RR 0.51 [0.34, 0.76] | 1 study · 854 participants | Moderate |
HAART regimen + topical treatment vs HAART regimen alone Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo Pain relief · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical thalidomide vs Another topical agent or placebo Pain relief · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
HAART regimen + topical treatment vs HAART regimen alone Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |