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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

473 questions in 36 reviews · HIV/AIDS

current versions
No studies 38 · 8%Ungraded 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Depressive symptoms Beck Depression Inventory Score · People living with HIV infection
Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection (2013) · Cochrane
no estimate extracted3 studies · 447 participantsLow
Intervention NR
Death or lost to care · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.46 [0.29, 0.71]4 studies · 39090 participantsModerate
Intervention NR
Lost to care · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.55 [0.45, 0.69]4 studies · 39090 participantsLow
Intervention NR
Death · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.34 [0.13, 0.87]4 studies · 39090 participantsLow
Intervention NR
Death or lost to care · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.7 [0.47, 1.02]4 studies · 56360 participantsVery low
Intervention NR
Lost to care · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.3 [0.17, 0.54]4 studies · 56360 participantsModerate
Intervention NR
Death · HIV infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 1.1 [0.63, 1.92]4 studies · 55099 participantsVery low
Intervention NR
Death or lost to care · HIV‐infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.95 [0.62, 1.46]2 studies · 709 participantsModerate
Intervention NR
Lost to care · HIV‐infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 0.81 [0.3, 2.21]2 studies · 709 participantsModerate
Intervention NR
Death · HIV‐infected patients
Decentralising HIV treatment in lower‐ and middle‐income countries (2013) · Cochrane
RR 1.03 [0.64, 1.65]2 studies · 709 participantsModerate
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Death · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 3 [0.12, 73.06]2 studies · 343 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 0.96 [0.06, 14.87]2 studies · 122 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
OR 0.64 [0.24, 1.75]1 study · 94 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 1.11 [0.86, 1.43]1 study · 67 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Mean weight gain per year in kg · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 94 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Mean height gain per year in cm · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 94 participantsVery low
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Mean standardized score on Beery VMI at 144 weeks · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 82 participantsVery low
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 1.5 [0.25, 8.85]2 studies · 343 participantsVery low
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
OR 0.7 [0.39, 1.24]2 studies · 343 participantsVery low
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 0.96 [0.84, 1.09]2 studies · 238 participantsLow
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Weight gain per year in kg · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 300 participantsLow
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Height gain per year in cm · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 300 participantsLow
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Standardized score on Beery VMI at 144 weeks · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extracted1 study · 272 participantsLow
IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Patient or population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)Settings: Thailand and CambodiaIntervention: IMMEDIATE initiation of cARTComparison: DEFERRED initiation of cART · HIV‐positive, treatment‐naive children aged one to 12 years old
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
no estimate extractedNRNo studies
Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART
Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane
RR 2.88 [0.12, 68.88]2 studies · 122 participantsVery low
Intervention NR
All‐cause mortality Death reports · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.55 [0.37, 0.82]3 studies · 262 participantsModerate
Intervention NR
All clinic visits ‐ URI · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.75 [0.55, 1.03]1 study · 854 participantsModerate
Intervention NR
All clinic visits ‐ pneumonia · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.89 [0.76, 1.04]1 study · 854 participantsModerate
Intervention NR
All clinic visits ‐ ear infection · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.78 [0.55, 1.11]1 study · 854 participantsModerate
Intervention NR
Mortality at 12 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.88 [0.52, 1.49]1 study · 847 participantsModerate
Intervention NR
CD4 count · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 399 participantsModerate
Intervention NR
Duration of hospitalisation ‐ All admissions · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 106 participantsModerate
Intervention NR
Change in appetite at 6 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 99 participantsModerate
Intervention NR
Anthropometric Z scores ‐ WAZ at 6 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 99 participantsModerate
Intervention NR
Anthropometric Z scores ‐ HAZ at 6 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 99 participantsModerate
Intervention NR
Anthropometric Z scores ‐ WHZ at 6 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 99 participantsModerate
Intervention NR
Child growth at 12 months ‐ Wasting Anthropometric measurements at monthly clinic visits · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.25 [0.06, 1.05]1 study · 41 participantsLow
Intervention NR
Child growth at 12 months ‐ Stunting Anthropometric measurements at monthly clinic visits · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.67 [0.34, 1.32]1 study · 29 participantsLow
Intervention NR
CD4 counts at 12 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 56 participantsLow
Intervention NR
Viral load at 12 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 56 participantsLow
Intervention NR
Viral load at 9 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 85 participantsModerate
Intervention NR
Mortality at 9 months Hospital records and verbal autopsies · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.31 [0.07, 1.42]1 study · 96 participantsLow
Intervention NR
CD4 % at 9 months · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
no estimate extracted1 study · 85 participantsModerate
Intervention NR
All clinic visits ‐ watery diarrhoea · Children with HIV infection
Micronutrient supplementation for children with HIV infection (2013) · Cochrane
RR 0.51 [0.34, 0.76]1 study · 854 participantsModerate
HAART regimen + topical treatment vs HAART regimen alone
Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo
Pain relief · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies
Topical thalidomide vs Another topical agent or placebo
Pain relief · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies
Topical corticosteroids vs Another topical agent or placebo
Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo
Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies
HAART regimen + topical treatment vs HAART regimen alone
Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
Topical treatments for HIV‐related oral ulcers (2012) · Cochrane
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…0 studiesNo studies