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Evidence found and GRADE certainty

122 questions · 185 findings · 7 reviews · Oral and maxillofacial surgery

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No studies found 0 · 0%GRADE not reported 175 · 94.6%Very low 0 · 0%Low 10 · 5.4%Moderate 0 · 0%High 0 · 0%

Second molar distally inclined at extraction vs Second molar upright at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, distal inclination of the second molar vs upright was not significantly associated with space closure (OR 1.18; not GRADE-rated).

1 finding from 1 review

Unilateral extraction of the mandibular first permanent molar vs Bilateral extraction of the mandibular first permanent molars

Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found midline deviation more likely after unilateral than bilateral extraction (OR 11.6; single study; not GRADE-rated).

1 finding from 1 review

M2 Demirjian stages F-G vs Second molar at Demirjian stage D-E at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage F-G vs D-E was not significantly associated with space closure (OR 0.68; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage G-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage A-D vs G-H was not significantly associated with space closure (OR 2.75; not GRADE-rated).

1 finding from 1 review

Extraction of the mandibular permanent first molar vs Not applicable (single-group prevalence)

Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

After mandibular first molar extraction, the second premolar was rotated in about 60% of cases (2 studies; very imprecise; not GRADE-rated).

1 finding from 1 review

Male sex vs Female sex

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, sex was not significantly associated with space closure (OR 1.38; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar)

In the maxilla, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 4.78; low certainty).

1 finding from 1 review

Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P)

Lactobacillus spp. mean levels/counts · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

No significant difference in Lactobacillus spp. presence was reported; GRADE was not reported.

1 finding from 1 review

M2 Demirjian stages F-G vs M2 Demirjian stages E-D

Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction

In the maxilla, M2 Demirjian stages F-G were not associated with a statistically significant difference in space closure odds.

1 finding from 1 review

Second molar at Demirjian stage E-F at extraction vs Second molar at Demirjian stage G-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage E-F vs G-H was not significantly associated with space closure (OR 4.44; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, earlier Demirjian stage A-D (vs F-H) increases odds of space closure (OR 3.11; low certainty).

1 finding from 1 review

Second molar mesially inclined at extraction vs Second molar upright at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, mesial inclination of the second molar vs upright was not significantly associated with space closure (OR 0.68; not GRADE-rated).

1 finding from 1 review

Extraction at patient age <8 years vs Extraction at patient age >10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction before age 8 (vs after 10) increases odds of space closure (OR 5.01; low certainty).

1 finding from 1 review

Age 8-10 years vs Extraction at patient age >10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).

1 finding from 1 review

Extraction of the mandibular permanent first molar vs Not applicable (single-group prevalence)

Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

After mandibular first molar extraction, the second molar was rotated in about 77% of cases (2 studies; very imprecise; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 3.81; low certainty).

1 finding from 1 review

Dental crowding present vs Dental spacing present

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found space closure more likely with crowding than spacing (OR 5.9; single study; not GRADE-rated).

1 finding from 1 review