Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

260 questions · 357 findings · 37 reviews · Dental caries

No studies found 24 · 6.7%GRADE not reported 257 · 72%Very low 37 · 10.4%Low 27 · 7.6%Moderate 4 · 1.1%High 8 · 2.2%

Older child age (months) vs Younger age (reference)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Age 48-59 months was associated with higher odds of ECC (OR 2.602).

2 findings from 1 review

Timing of first dental visit vs Reference visit timing

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

An early first dental visit was associated with much lower odds of ECC (OR 0.042).

2 findings from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Proportion of ancient skulls with at least one non-carious cervical lesion (NCCL) · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)

About 1.4% of ancient skulls (pooled) had at least one NCCL; crude 17/805 (2.11%) across 6 studies (ungraded, substantial heterogeneity I2=69%).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)

Non-carious cervical lesions affected a pooled proportion of about 0.4% of teeth in ancient skulls (4 studies; ungraded, very high heterogeneity I2=97.6%).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries prevalence · 12-year-old children (permanent dentition) in Africa

Pooled caries prevalence in Uganda was 0.27 (95% CI 0.126 to 0.418; 3 article(s); not GRADE-rated).

23 findings from 1 review
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Caries severity measurement (mean number of decayed, missing and filled permanent teeth, DMFT; WHO criteria) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries · 12-year-old children (permanent dentition) in Africa

Pooled mean DMFT in Sudan was 0.49 (95% CI 0.461 to 0.519; 1 article(s); not GRADE-rated).

22 findings from 1 review
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Mixed breast- and bottle-feeding vs Bottle feeding

Early childhood caries (ECC) · Healthy children under 6 years in South Africa

No significant difference in caries odds was found between mixed breast-and-bottle-fed and bottle-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable

Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa

The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.

2 findings from 1 review

Not applicable (single-group prevalence) vs Not applicable

Caries experience (mean DMFT) · Children aged 12 years (plus or minus one year) in Africa

The pooled mean DMFT score was 1.0900 (95% CI 0.9143 to 1.2657); GRADE was not reported.

2 findings from 1 review

Higher parental education (tertiary) vs Parental high school (secondary) education

Early childhood caries (ECC) · Healthy children under 6 years in South Africa

Parental tertiary education (vs high-school education) was associated with about 1.8 times higher odds of early childhood caries in South Africa (OR 1.77, 95% CI 1.22-2.57; 2 studies; not GRADE-rated).

1 finding from 1 review