Hyperbaric oxygen vs control without HBOT
Pain score change at 12 months · any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw
1 finding from 1 review
- no estimate extracted2 studies · 157 participantsModerate
Findings
What do systematic reviews say?
394 questions · 412 findings · 112 reviews
No studies found 51 · 12.4%GRADE not reported 41 · 10%Very low 86 · 20.9%Low 121 · 29.4%Moderate 84 · 20.4%High 29 · 7%
Hyperbaric oxygen vs control without HBOT
Complete resolution or significant improvement of osteoradionecrosis · any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw
Hyperbaric oxygen therapy (HBOT) showed no clear difference in complete resolution or significant improvement of osteoradionecrosis compared with control without HBOT (low certainty).
1 finding from 1 review
- RR 1.26 [0.87, 1.82]3 studies · 239 participantsLow
HFNC vs standard oxygen therapy
Duration of oxygen therapy (hours) · infants with bronchiolitis
1 finding from 1 review
- High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 2132 participantsLow
Continuous positive airway pressure (CPAP) vs supplemental oxygen
Bronchopulmonary dysplasia at 28 days · preterm infants with respiratory distress for initial respiratory support
It is very uncertain whether CPAP changes bronchopulmonary dysplasia (oxygen dependency at 28 days) compared with supplemental oxygen (very low certainty).
1 finding from 1 review
- Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes onlyRR 1.04 [0.35, 3.13]2 studies · 209 participantsVery low
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
All‐cause mortality: all ECMO studies · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to lower all‐cause mortality: all ECMO studies compared with conventional care (moderate certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 0.8 [0.7, 0.92]5 studies · 756 participantsModerate
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
All‐cause mortality: VV ECMO subgroup · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to lower all‐cause mortality: VV ECMO subgroup compared with conventional care (moderate certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 0.77 [0.62, 0.96]2 studies · 429 participantsModerate
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
All‐cause mortality: VA ECMO subgroup · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in all‐cause mortality: VA ECMO subgroup compared with conventional care (low certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 0.5 [0.18, 1.41]1 study · 42 participantsLow
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
All‐cause mortality at 6 months (subgroup) · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in all‐cause mortality: ECPR subgroup compared with conventional care (moderate certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 0.76 [0.52, 1.13]2 studies · 285 participantsModerate
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
Major hemorrhage · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to higher major hemorrhage: all available studies compared with conventional care (moderate certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 3.32 [1.9, 5.82]4 studies · 577 participantsModerate
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care
Neurologic injury: all available studies · severe cardiorespiratory failure and cardiac arrest
Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in neurologic injury: all available studies compared with conventional care (moderate certainty).
1 finding from 1 review
- Extracorporeal membrane oxygenation for critically ill adults 2023 · Cochrane Headline outcomes onlyRR 2.83 [0.36, 22.42]2 studies · 286 participantsModerate
Nitrous oxide/oxygen vs placebo or no intervention
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
It is very uncertain whether nitrous oxide/oxygen changes behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (very low certainty).
1 finding from 1 review
- SMD 0.69 [0.13, 1.26]1 study · 52 participantsVery low
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Change in ulcer size · people with venous leg ulcers
1 finding from 1 review
- no estimate extracted1 study · 61 participantsVery low
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Procedural pain · people with venous leg ulcers
1 finding from 1 review
- no estimate extracted1 study · 61 participantsVery low
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Costs · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Health related quality of life · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Adverse events · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Ulcer healing · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Aqueous oxygen peroxide vs placebo (saline solution or sterile water)
Number of wounds healed · people with venous leg ulcers
It is very uncertain whether aqueous oxygen peroxide changes number of wounds healed ‐ per protocol ‐ after 12 months of compared with sterile water (very low certainty).
1 finding from 1 review
- RR 1.88 [1.1, 3.2]1 study · 34 participantsVery low
Intervention not reported
Mean maternal arterial oxygen tension (mm Hg) (PaO2) · low‐risk term pregnant women undergoing elective caesarean section under regional anaesthesia
1 finding from 1 review
- Supplemental oxygen for caesarean section during regional anaesthesia 2016 · Cochrane Headline outcomes onlyno estimate extracted6 studies · 241 participantsVery low
Intervention not reported
Mean maternal oxygen saturation (%) · low‐risk term pregnant women undergoing elective caesarean section under regional anaesthesia
1 finding from 1 review
- Supplemental oxygen for caesarean section during regional anaesthesia 2016 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 209 participantsVery low