Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

247 questions · 258 findings · 21 reviews

No studies found 84 · 32.6%GRADE not reported 12 · 4.7%Very low 78 · 30.2%Low 56 · 21.7%Moderate 22 · 8.5%High 6 · 2.3%

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Incidence of admissions to the ICU · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ICU admission compared with placebo + standard care (very low certainty).

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

Intravenous magnesium sulfate + standard care may leads to lower proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (low certainty).

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring non‐invasive ventilation · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether intravenous magnesium sulfate + standard care changes proportion of people requiring non‐invasive ventilation compared with placebo + standard care (very low certainty).

1 finding from 1 review

Magnesium sulphate or magnesium sulphate + salbutamol vs salbutamol

Clinical severity score (CSS) (Wang score; range 0 to 12; higher = poorer outcome) measured at 0 to 24 hoursafter treatment · children from 1 month to 24 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review

Magnesium sulphate or magnesium sulphate + salbutamol vs salbutamol

Clinical severity score (CSS) (Wang score; range 0 to 12; higher = poorer outcome) measured 25 to 48 hoursafter treatment · children from 1 month to 24 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review