What do systematic reviews say?

Postoperative use of LNG‐IUD vs expectant management

• Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Very low

Postoperative use of LNG‐IUD vs expectant management

• Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 95 participants
  Very low

Postoperative use of LNG‐IUD vs expectant management

• Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Very low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.82, 1.1]
  4 studies · 985 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.13 [0.08, 0.21]
  4 studies · 985 participants
  Moderate

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.84, 1.08]
  3 studies · 943 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 2.14 [0.93, 4.95]
  2 studies · 282 participants
  Low

Single vs multiple embryo transfer

Single may leads to lower live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.67 [0.59, 0.75]
  12 studies · 1904 participants
  Low

Single vs multiple embryo transfer

Single probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.16 [0.12, 0.22]
  13 studies · 1952 participants
  Moderate

Single vs multiple embryo transfer

Single may leads to lower clinical pregnancy compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.7 [0.64, 0.77]
  10 studies · 1860 participants
  Low

Single vs multiple embryo transfer

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.96 [0.66, 1.42]
  7 studies · 1560 participants
  Low

Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy

It is very uncertain whether any anti‐adhesion therapy changes live birth a compared with placebo or no treatment following operative hysteroscopy (very low certainty).

• Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility 2017 · Cochrane Headline outcomes only
  OR 0.94 [0.42, 2.12]
  2 studies · 107 participants
  Very low

Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy

Any anti‐adhesion therapy may leads to lower presence of intrauterine adhesions at second‐look hysteroscopy… compared with placebo or no treatment following operative hysteroscopy (low certainty).

• Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility 2017 · Cochrane Headline outcomes only
  OR 0.35 [0.21, 0.6]
  8 studies · 560 participants
  Low

Any anti‐adhesion therapy vs anti‐adhesion therapy B following operative hysteroscopy

Any anti‐adhesion therapy A showed no clear difference in live birth a compared with anti‐adhesion therapy B following operative hysteroscopy (low certainty).

• Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility 2017 · Cochrane Headline outcomes only
  OR 1.48 [0.57, 3.83]
  3 studies · 180 participants
  Low

Any anti‐adhesion therapy vs anti‐adhesion therapy B following operative hysteroscopy

Any anti‐adhesion therapy A may leads to lower presence of intrauterine adhesions at second‐look hysteroscopy (6‐12… compared with anti‐adhesion therapy B following operative hysteroscopy (low certainty).

• Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility 2017 · Cochrane Headline outcomes only
  OR 0.55 [0.36, 0.83]
  5 studies · 451 participants
  Low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

It is very uncertain whether day 3 changes live birth rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

• Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
  RR 1.05 [0.89, 1.23]
  3 studies · 1200 participants
  Very low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

It is very uncertain whether day 3 changes ongoing pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

• Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
  RR 0.98 [0.85, 1.12]
  6 studies · 1740 participants
  Very low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

It is very uncertain whether day 3 changes clinical pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

• Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
  RR 1.08 [0.98, 1.19]
  12 studies · 2461 participants
  Very low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Day 3 showed no clear difference in multiple pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

• Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.86, 1.44]
  8 studies · 1837 participants
  Moderate

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

• Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
  RR 1.16 [0.84, 1.6]
  9 studies · 2153 participants
  Moderate