Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

778 questions · 809 findings · 116 reviews

No studies found 205 · 25.3%GRADE not reported 111 · 13.7%Very low 225 · 27.8%Low 155 · 19.2%Moderate 85 · 10.5%High 28 · 3.5%

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Denovo urgency or urgency incontinence · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in de novo urgency or urgency incontinence (short term, up to 12 months) compared with obturator lateral‐to‐medial approach (low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Vaginal tape erosion · women with stress urinary incontinence

It is very uncertain whether obturator medial‐to‐lateral approach changes vaginal tape erosion (short and medium term, up to 5 years) compared with obturator lateral‐to‐medial approach (very low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Repeat surgery for urinary incontinence · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in repeat incontinence surgery (short term, up to 12 months) compared with obturator lateral‐to‐medial approach (low certainty).

2 findings from 1 review

Unilateral cleft lip and palate (UCLP) vs Bilateral cleft lip and palate (BCLP)

Plaque · Patients with cleft lip and palate (CLP)

Plaque index does not differ significantly between unilateral and bilateral cleft lip and palate (MD -0.13, 95% CI -0.38 to 0.12; ungraded).

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes presence or persistence of OME (3 years ‐ long‐term) № of… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes hearing: return to normal hearing at 6 to 9 months № of… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes presence/persistence of OME ‐ over 12 months № of participants: 254… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Specific adverse events: haemorrhage · children aged 6 months to 12 years with otitis media with effusion (OME)

Adenoidectomy and bilateral ventilation tubes showed no clear difference in adverse event: haemorrhage № of participants: 791(2 RCTs) compared with bilateral ventilation tubes only (low certainty).

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes hearing: proportion of children with hearing returned to normal (12… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Motor alignment at distance fixation Measured using the PACT at 1 year · people with intermittent exotropia, aged over 6 years

Lateral rectus recession and medial rectus plication showed no clear difference in motor alignment at distance fixation Measured using the PACT at 1 year compared with lateral rectus recession and medial rectus resection (low certainty).

1 finding from 1 review