Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

289 questions · 326 findings · 19 reviews · Drugs and Alcohol

No studies found 13 · 4%GRADE not reported 33 · 10.1%Very low 108 · 33.1%Low 109 · 33.4%Moderate 52 · 16%High 11 · 3.4%

Any Psychosocial intervention plus pharm vs psychosocial interventions

Harmful alcohol use · alcohol use disorder
2 findings from 1 review

Any Psychosocial intervention plus pharm vs psychosocial interventions

Retention [ · alcohol use disorder

Pharmacologic intervention along with psychosocial intervention showed no clear difference in retention compared with psychosocial intervention alone (moderate certainty).

1 finding from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Harmful alcohol use ‐ not measured · alcohol use disorder

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Retention [ · alcohol use disorder

Pharmacologic intervention showed no clear difference in retention compared with another pharmacologic intervention (low certainty).

2 findings from 1 review

Integrated CBT vs Twelve Step Facilitation

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review

Integrated CBT vs Twelve Step Facilitation

Percent of days abstinent · co‐occurring depression and substance use disorders
2 findings from 1 review

Motivational interviewing/mindfulness and cognitive skills vs waiting list control

Abstinence from drug use · drug‐using offenders with co‐occurring mental health problems

Motivational interviewing/mindfulness and cognitive skills showed no clear difference in abstinence from drug use compared with waiting list control (low certainty).

1 finding from 1 review