The intervention showed no clear difference in combination NRT & bupropion versus placebo Smoking cessation (low certainty).
The intervention probably leads to higher varenicline versus placebo Smoking cessation (moderate certainty).
Biomedical risk assessment showed no clear difference in feedback on smoking exposure Smoking cessation at longest compared with standard care or minimal intervention (moderate certainty).
Motivational interviewing showed no clear difference in smoking cessation at ≥ 6 months compared with another smoking cessation intervention (low certainty).
It is very uncertain whether telephone quitline referral changes quitline referral vs control compared with no treatment or usual care (very low certainty).
It is very uncertain whether telephone quitline referral changes health system telephone counselling vs quitline compared with no treatment or usual care (very low certainty).
Pharmacotherapy plus counselling leads to higher quit at longest compared with no pharmacotherapy or placebo plus counselling (high certainty).
Nicotine replacement therapy for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (moderate certainty).
Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty).
Fluoexetine showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (low certainty).
Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in mean birthweight (g) compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in miscarriage and spontaneous abortion compared with control (low certainty).
Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).
Bupropion showed no clear difference in mean birthweight (g) compared with control (low certainty).
The review found no eligible studies for this question.
The intervention showed no clear difference in smoking abstinence (low certainty).
It is very uncertain whether more changes smoking abstinence compared with less intensive behavioral smoking cessation support (very low certainty).
It is very uncertain whether multi‐issue support changes smoking abstinence compared with smoking cessation support only (very low certainty).
Print‐based self‐help probably leads to higher abstinence ‐ non‐tailored self‐help compared with no materials (moderate certainty).