Oral mucositis (severe) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone
Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (severe) compared with chlorhexidine mouthwash; GRADE not reported.
1 finding from 1 review
Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
Positive response (not defined) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
Triamcinolone acetonide 0.1% ointment (topical) led to higher positive response (not defined) compared with phenytoin syrup mouthwash (30 mg in 5 mL); GRADE not reported.
1 finding from 1 review
Plaque · Adults with dental implants and peri-implant mucositis at baseline
Mechanical debridement plus topical minocycline showed no clear difference in plaque compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline
Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
1 finding from 1 review
Change in probing pocket depth (worst sites) · Adults with dental implants and peri-implant mucositis at baseline
Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
1 finding from 1 review
Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline
Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).
2 findings from 1 review
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes burning sensation (VAS 0-100) compared with placebo or no active treatment (very low certainty).
2 findings from 1 review
MD -51.02 [-72.85, -29.20]
2 studies · 85 participants
Very low
MD -38.79 [-52.06, -25.53]
2 studies · 85 participants
Very low
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether 3Mix (ciprofloxacin + metronidazole + minocycline) changes clinical failure compared with simvastatin (very low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) may leads to higher clinical failure compared with 3Mixtatin (low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in radiological failure compared with 3Mix pulpectomy; GRADE not reported.
1 finding from 1 review
Normalcy of diet (mean worst ability to eat, 1 to 4 scale) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (mean worst ability to eat, 1 to 4 scale) compared with placebo; GRADE not reported.
1 finding from 1 review
Oral mucositis (any severity) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.
4 findings from 1 review
RR 0.96 [0.88, 1.05]
4 studies · 655 participants
GRADE not reported
Two studies of KGF versus placebo in children were unclear in reporting; no usable data could be presented
2 studies
GRADE not reported
RR 0.95 [0.90, 1.00]
2 studies · 374 participants
GRADE not reported
Show 1 more finding
Number of days in hospital · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.
1 finding from 1 review
Number of days unable to take medicine orally · Adults with cancer receiving treatment
The review found no eligible studies for this question.
1 finding from 1 review