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What do systematic reviews say?

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Evidence found and GRADE certainty

130 questions · 134 findings · 34 reviews · Headline outcomes only

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No studies found 21 · 15.7%GRADE not reported 0 · 0%Very low 41 · 30.6%Low 48 · 35.8%Moderate 16 · 11.9%High 8 · 6%

Mobile bearing vs fixed bearing prosthesis

Function ‐ measured as KSS function Knee Society Score, function. Scale from 0 to 100 (higher scores indicates better function) · patients with posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and…
1 finding from 1 review

Intervention not reported

Achievement of at least 50% reduction in headache severity Post‐treatment Higher scores indicate more children with reduced headache · children or adolescents with headaches

It is very uncertain whether the intervention changes achievement of at least 50% reduction in headache severity… (very low certainty).

1 finding from 1 review

Supplemental IV crystalloid vs control IV crystalloid volume

Risk of suffering a serious adverse event, reported dichotomously as the occurrence of any of: admission to high‐dependency unit, postoperative cardiac or respiratory complication, or death · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Supported employment vs other vocational approaches

Employment ‐ obtained any job during the study (high=better) · adults with severe mental illness

It is very uncertain whether supported employment changes employment ‐ obtained any job during the study (high=better) compared with other vocational approaches (very low certainty).

1 finding from 1 review

Discontinuation with high‐intensity psychological interventions vs continuation

Risk of relapse (as defined by study authors) (HR) · participants with long‐term antidepressants for depressive disorders

Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).

1 finding from 1 review