Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

320 questions · 331 findings · 64 reviews · Headline outcomes only

No studies found 44 · 13.3%GRADE not reported 24 · 7.3%Very low 120 · 36.3%Low 90 · 27.2%Moderate 37 · 11.2%High 16 · 4.8%

Early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

1 finding from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Functional assessment using a patient reported outcome measure: · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Active finger range of motion · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Tendon rupture · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse event (tendon rupture) compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Summary of findings table 1: comparison of operation types: early results of needle fasciotomy vs limited fasciectomy

DASH hand function score at 3 months Major outcome group 1 (hand function) (scores between 0 and 100, where 0 represents no impairment in hand function and 100 represents maximum impairment in hand function) · 125 hands in 121 participants with Dupuytren's disease of the fingers for early outcomes (van Rijssen 2006)
1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Recovered · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) may leads to higher global state: recovery (assessed by proportion recovered, as defined… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: disengagement from services (assessed by proportion disengaged, as defined by the study, at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) probably leads to lower service use: disengagement from services (assessed by proportion… compared with treatment (moderate certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in service use: admission to psychiatric hospital (assessed by… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Mental state: 1b.Average end point score on various outcomes‐PANSS (medium‐term) ‐ Medium term ‐ PANSS general psychopathology end point score (low = favourable) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review

Very early cerebral revascularization vs delayed treatment

Perioperative death and strokes · people with recently symptomatic carotid artery stenosis

It is very uncertain whether very early cerebral revascularization changes stroke and Death < 30 days compared with delayed treatment (very low certainty).

2 findings from 1 review