Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

110 questions · 114 findings · 10 reviews · Neuromuscular

No studies found 25 · 21.9%GRADE not reported 5 · 4.4%Very low 29 · 25.4%Low 20 · 17.5%Moderate 27 · 23.7%High 8 · 7%

Monthly pulsed high‐dose dexamethasone vs prednisolone

≥ 1 point improvement on INCAT disability score at 12 months · patients with chronic inflammatory demyelinating polyradiculoneuropathy

Monthly pulsed high‐dose dexamethasone may leads to higher ≥ 1 point improvement on INCAT disability score at 12 months compared with oral prednisolone (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants who completed the study and did not restart IVIg therapy after IVIg withdrawal · people with CIDP

Interferon beta‐1a showed no clear difference in participants who completed the study and did not restart IVIg… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Improvement in disability grade after 4 weeks · patients with Guillain‐Barré syndrome
4 findings from 1 review
Show 1 more finding

Corticosteroids vs control

Death or disability after 1 year · patients with Guillain‐Barré syndrome

Corticosteroid showed no clear difference in death or disability after 1 year compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Adverse events ‐ Diabetes mellitus requiring insulin · patients with Guillain‐Barré syndrome

Corticosteroid leads to higher adverse events ‐ diabetes mellitus requiring insulin compared with control (high certainty).

1 finding from 1 review

Corticosteroids vs control

Adverse events: hypertension · patients with Guillain‐Barré syndrome

Corticosteroid leads to lower adverse events ‐ hypertension compared with control (high certainty).

1 finding from 1 review