Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone
Zoledronate showed no clear difference in number of participants who experienced side effects related to use… compared with pamidronate or risedronate (low certainty).
1 finding from 1 review
Intervention not reported
Overall survival## · patients with multiple myeloma
The intervention showed no clear difference in overall survival## (moderate certainty).
1 finding from 1 review
Intervention not reported
Progression‐free survival### · patients with multiple myeloma
The intervention showed no clear difference in progression‐free survival### (low certainty).
1 finding from 1 review
Intervention not reported
Vertebral fractures · patients with multiple myeloma
The intervention probably leads to lower vertebral fractures (moderate certainty).
1 finding from 1 review
Intervention not reported
Non‐vertebral fractures · patients with multiple myeloma
The intervention showed no clear difference in non‐vertebral fractures (moderate certainty).
1 finding from 1 review
Intervention not reported
Skeletal‐related events · patients with multiple myeloma
The intervention probably leads to lower skeletal‐related events (moderate certainty).
1 finding from 1 review
Intervention not reported
Pain · patients with multiple myeloma
It is very uncertain whether the intervention changes pain (very low certainty).
1 finding from 1 review
Intervention not reported
Osteonecrosis of jaw · patients with multiple myeloma
The intervention showed no clear difference in osteonecrosis of jaw (low certainty).
1 finding from 1 review
Number of participants who needed orthopaedic surgery (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in quality of life measures (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in hearing thresholds (not measured) · Paget's disease of bone
1 finding from 1 review
Withdrawals due to adverse events · Paget's disease of bone
It is very uncertain whether zoledronate changes number of participants who withdrew due to adverse events… compared with pamidronate or risedronate (very low certainty).
1 finding from 1 review
Number of participants with change in bone pain¹ assessed on VAS. · Paget's disease of bone
It is very uncertain whether zoledronate changes number of participants with change in bone pain¹ assessed on VAS. compared with pamidronate or risedronate (very low certainty).
1 finding from 1 review
Fracture · Paget's disease of bone
1 finding from 1 review