Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 107 findings · 15 reviews · Headline outcomes only

No studies found 19 · 17.8%GRADE not reported 5 · 4.7%Very low 33 · 30.8%Low 23 · 21.5%Moderate 23 · 21.5%High 4 · 3.7%

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… may leads to lower anaemia (defined as haemoglobin below the WHO cut‐off, adjusted for… compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… may leads to lower iron deficiency (as defined by study authors, based on a biomarker… compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Vitamin A deficiency · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… showed no clear difference in vitamin A deficiency (as defined by the study authors) compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Any adverse effects (hookworm infection risk) · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… may leads to higher any adverse effects (hookworm infection risk) compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Diarrhoea · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether rice fortified with iron alone or in combination with other… changes diarrhoea (as defined by study authors) compared with unfortified rice (no micronutrients added) (very low certainty).

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with exercise‐induced asthma

The review found no eligible studies for this question.

1 finding from 1 review