Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

704 questions · 710 findings · 81 reviews · Headline outcomes only

No studies found 227 · 32%GRADE not reported 38 · 5.4%Very low 178 · 25.1%Low 178 · 25.1%Moderate 80 · 11.3%High 9 · 1.3%

Active NRT vs placebo ‐ rs1051730 ‐ non‐Hispanic white

Abstinence at end of treatment ‐ homozygous minor · people who smoke

Active NRT may leads to higher abstinence at end of treatment ‐ homozygous minor compared with placebo ‐ rs1051730 ‐ non‐Hispanic white (low certainty).

1 finding from 1 review

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Clinical relapse · people with inflammatory bowel disease

High‐treatment‐dose vitamin D (greater than 1000 IU/day) showed no clear difference in clinical relapse at end of study (52 weeks) compared with low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day) (low certainty).

1 finding from 1 review

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Withdrawals due to adverse events · people with inflammatory bowel disease

It is very uncertain whether high‐treatment‐dose vitamin D (greater than 1000 IU/day) changes withdrawals due to adverse events compared with low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day) (very low certainty).

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Patient outcome: treatment adherence: not adherent at · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes patient outcome: treatment adherence: not adherent at compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Bladder training vs no treatment

Participant‐reported cure or improvement: immediately after treatment · overactive bladder

It is very uncertain whether summary of findings table ‐ Bladder training changes participant‐reported cure or improvement: immediately after treatment compared with no treatment (very low certainty).

1 finding from 1 review