Treatment burden · adults (aged 16 years and over) with CF
Digital technology (web‐based platform CFHealthHub) probably leads to higher treatment burden: CFQ‐R treatment burden domain score (higher score… compared with usual care (moderate certainty).
1 finding from 1 review
QoL · adults (aged 16 years and over) with CF
Digital technology (web‐based platform CFHealthHub) showed no clear difference in qoL: CFQ‐R domain scores at end of study compared with usual care (moderate certainty).
1 finding from 1 review
FEV1 % predicted · adults (aged 16 years and over) with CF
Digital technology (web‐based platform CFHealthHub) showed no clear difference in FEV1: mean FEV1 % predicted at end of study compared with usual care (low certainty).
1 finding from 1 review
Adherence to inhaled therapies cMPR · children, adolescents or adults with CF
Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).
1 finding from 1 review
Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF
Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).
1 finding from 1 review
Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF
Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).
1 finding from 1 review
QoL · children, adolescents or adults with CF
Summary of findings: psychological interventions may leads to higher qoL CFQ‐R (Quittner 2009) compared with usual care (low certainty).
1 finding from 1 review
FEV1 % predicted · children, adolescents or adults with CF
Summary of findings: psychological interventions showed no clear difference in lung function FEV1 % predicted compared with usual care (moderate certainty).
1 finding from 1 review
Pulmonary exacerbations · children, adolescents or adults with CF
1 finding from 1 review
Frequency of transfusion (transfused volume/year) · people with non‐transfusion‐dependent β‐thalassaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Transfusion‐free interval (days) · people with non‐transfusion‐dependent β‐thalassaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Haemoglobin (g/dL) · people with non‐transfusion‐dependent β‐thalassaemia
1 finding from 1 review
Measures of HbF · people with non‐transfusion‐dependent β‐thalassaemia
1 finding from 1 review
QoL · people with non‐transfusion‐dependent β‐thalassaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · people with non‐transfusion‐dependent β‐thalassaemia
It is very uncertain whether single foetal haemoglobin inducer at any dose or duration changes adverse events compared with usual care or placebo (very low certainty).
1 finding from 1 review
Time to next pulmonary exacerbation · adolescents and adults with cystic fibrosis
Digital technology probably leads to higher time to next pulmonary exacerbation compared with usual care (moderate certainty).
1 finding from 1 review
Exacerbations (number of people experiencing ≥ 1 exacerbations) · adolescents and adults with cystic fibrosis
Digital technology showed no clear difference in number of pulmonary exacerbations: number of participants… compared with usual care (moderate certainty).
1 finding from 1 review
Quality of life: change from baseline in CFQ‐R · adolescents and adults with cystic fibrosis
Digital technology showed no clear difference in qoL: change from baseline in CFQ‐R score compared with usual care (moderate certainty).
1 finding from 1 review
FEV1 (% predicted): mean change from baseline · adolescents and adults with cystic fibrosis
1 finding from 1 review
IV antibiotics: number of days on IV antibiotics · adolescents and adults with cystic fibrosis
Digital technology showed no clear difference in IV antibiotics: number of days on IV antibiotics compared with usual care (low certainty).
1 finding from 1 review