Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis

Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Surgical site infections: liver transplant recipients Time frame: 30 days · solid organ transplant recipients

It is very uncertain whether extended changes surgical site infections: liver transplant recipients Time frame: 30… compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Graft loss including death · solid organ transplant recipients

It is very uncertain whether extended changes graft loss (including death with functioning graft) Time frame: 30… compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Other infection: septicaemia Time frame: 2 to 6 weeks · solid organ transplant recipients

It is very uncertain whether extended changes other infection: septicaemia Time frame: 30 days compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Other infection: pneumonia Time frame: 30 days · solid organ transplant recipients

It is very uncertain whether extended changes other infection: pneumonia Time frame: 30 days compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Surgical site infections: kidney transplant recipients Time frame: 30 days · solid organ transplant recipients

It is very uncertain whether extended changes surgical site infections: kidney transplant recipients Time frame:… compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Oral vs topical antibiotics

Active trachoma · people (any age) with active trachoma

Oral showed no clear difference in active trachoma Clinical assessment: active trachoma defined as TF,… compared with topical antibiotic (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of AAD · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention probably leads to lower incidence of AAD (moderate certainty).

1 finding from 1 review