Neurodevelopmental disability at 18 to 24 months among survivors · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in neurodevelopmental disability at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Seizure burden during hospitalisation · neonates
1 finding from 1 review
Mortality or neurodevelopmental disability at 18 to 24 months' corrected age ‐ not reported · neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mortality before hospital discharge · neonates
Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in mortality before hospital discharge compared with treatment of clinical seizures alone (low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates
Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with treatment of clinical seizures alone (low certainty).
1 finding from 1 review
Proportion of infants who develop sedation or drowsiness · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with levetiracetam (very low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop epilepsy post‐discharge compared with levetiracetam (very low certainty).
1 finding from 1 review
Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after first… compared with levetiracetam (very low certainty).
1 finding from 1 review
Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with clinically diagnosed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after maximal… compared with levetiracetam (very low certainty).
1 finding from 1 review
MRONJ (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
1 finding from 1 review
All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
1 study · 77 participants
GRADE not reported
Complications and side effects · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
Healing of MRONJ · People with established (manifest) MRONJ
Teriparatide 20 microg daily in addition to standard care showed no clear difference in healing of MRONJ (resolution of lesions) compared with placebo in addition to standard care (low certainty).
1 finding from 1 review
Healing of MRONJ (soft tissue healing) · Women with osteoporosis and established MRONJ
It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty).
1 finding from 1 review
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity and absence of infection) compared with bone surgery alone (very low certainty).
1 finding from 1 review
Healing of MRONJ (mucosal integrity, absence of infection, and no re-intervention) · People with established (manifest) MRONJ
It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).
1 finding from 1 review
Complications and side effects · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether autofluorescence-guided bone surgery changes healing of MRONJ compared with conventional bone surgery (very low certainty).
1 finding from 1 review
MRONJ (incidence proportion) · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
In both study arms, no case of postoperative MRONJ was observed (700 participants; 1 RCT); effect not estimable.
1 study · 700 participants
GRADE not reported
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty).
1 finding from 1 review