Findings

What do systematic reviews say?

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

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No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Intracameral mydriatics vs depot delivery systems

AE: participant‐reported ocular discomfort—week 1 · patients undergoing cataract surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intracameral mydriatics vs depot delivery systems

AE: participant‐reported ocular discomfort—month 1 · patients undergoing cataract surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical mydriatics vs intracameral mydriatics

Total time it took for the surgeon to perform phacoemulsification (seconds) · patients undergoing cataract surgery

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 48 participants
Very low

Topical mydriatics vs intracameral mydriatics

AE: participant‐reported ocular discomfort—week 1 · patients undergoing cataract surgery

It is very uncertain whether topical mydriatics changes AE: participant‐reported ocular discomfort—week 1 compared with intracameral mydriatics (very low certainty).

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
RR 10.57 [1.37, 81.34]
1 study · 555 participants
Very low

Topical mydriatics vs intracameral mydriatics

AE: participant‐reported ocular discomfort—month 1 · patients undergoing cataract surgery

Topical mydriatics probably leads to higher AE: participant‐reported ocular discomfort—month 1 compared with intracameral mydriatics (moderate certainty).

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
RR 2.51 [1.36, 4.65]
1 study · 543 participants
Moderate

Eculizumab vs placebo or alternative treatment

Requirement for KRT · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Ravulizumab vs placebo or alternative treatment

Requirement for KRT · adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
56 participants
Very low

Synsorb Pk vs placebo

Need for acute dialysis · patients with diarrhoea due to Shiga toxin‐producing E. coli

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Urtoxazumab (3.0 mg/kg) vs placebo

Need for acute dialysis · paediatric patients with diarrhoea due to Shiga toxin‐producing E. coli

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Urtoxazumab (1.0 mg/kg) vs placebo

Need for acute dialysis · paediatric patients with diarrhoea due to Shiga toxin‐producing E. coli

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antibiotics vs no treatment

Need for acute dialysis · patients with diarrhoea due to Shiga toxin‐producing E. coli

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bovine colostrum vs placebo

Need for acute dialysis · patients with diarrhoea due to Shiga toxin‐producing E. coli

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in intensity of the nystagmus waveform · infantile nystagmus syndrome

1 finding from 1 review

Surgical interventions for infantile nystagmus syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
Very low

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in foveation period durations of the waveform ‐ not reported · infantile nystagmus syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for infantile nystagmus syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mindfulness vs no treatment or waiting list

Academic achievement (

1 finding from 1 review

Mindfulness‐based psychological interventions for improving mental well‐being in medical students and junior doctors 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 79 participants
Very low

Active stimulation vs Placebo (sham/placebo device)

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Implanted spinal neuromodulation interventions for chronic pain in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Implanted spinal neuromodulation interventions for chronic pain in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Implanted spinal neuromodulation interventions for chronic pain in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Active stimulation + other intervention vs other intervention alone

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Implanted spinal neuromodulation interventions for chronic pain in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Implanted spinal neuromodulation interventions for chronic pain in adults 2021 · Cochrane Headline outcomes only
RR 25.81 [1.69, 393.31]
1 study · 44 participants
Very low

Psychological therapy vs usual care or attention control

Depression: meeting study criteria for depression at end of · people with stroke

It is very uncertain whether psychological therapy changes depression: meeting study criteria for depression at end of… compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke 2020 · Cochrane Headline outcomes only
RR 0.68 [0.49, 0.94]
2 studies · 607 participants
Very low

Psychological therapy vs usual care or attention control

Scoring above cut‐off points for a depressive disorder at end of treatment (Analysis 1.2) · people with stroke

1 finding from 1 review

Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Other outcomes included uncertainty, pain, sexually related symptoms, dyspnoea, and general symptoms. Data for any of these outcomes were not pooled due to considerable heterogeneity across all aspects. Magnitudes of effect were not reported · individuals with any cancer at any stage

1 finding from 1 review

Telephone interventions for symptom management in adults with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
2 participants
Very low