Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Ibuprofen vs morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

The review found no eligible studies for this question.

2 findings from 1 review

Ibuprofen vs morphine

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen probably leads to lower adverse events (reported in the first 7 days after the procedure) compared with morphine (moderate certainty).

1 finding from 1 review

Ibuprofen vs ketorolac

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

The review found no eligible studies for this question.

2 findings from 1 review

Ibuprofen vs placebo

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen showed no clear difference in adverse events (reported in the first 7 days after the procedure) compared with placebo (low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ serious adverse events Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ serious adverse eventsClinical or… compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Adverse effects of any severity (systemic symptoms) · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to higher participants with adverse events ‐ any systemic symptomClinical… compared with placebo (moderate certainty).

1 finding from 1 review