Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,733 questions · 1,794 findings · 326 reviews · Headline outcomes only

No studies found 243 · 13.5%GRADE not reported 96 · 5.4%Very low 597 · 33.3%Low 506 · 28.2%Moderate 303 · 16.9%High 49 · 2.7%

CHLORPROMAZINE vs RESERPINE

Global state: not improved ‐ short‐term GAF · patients with schizophrenia

CHLORPROMAZINE may leads to lower global state: Not improved (short term) compared with RESERPINE (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Mental state: Not improved (paranoid distortion) Multidimentional Scale for Rating Psychiatric Patients (short term) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes mental state: Not improved (paranoid distortion) Multidimentional… compared with RESERPINE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Functioning: not improved occupational adjustment (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in functioning: not improved occupational adjustment (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Adverse events ‐ toxic reaction (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in adverse events ‐ toxic reaction (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in leaving the study early ‐ due to adverse effects (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Patients with acute low‐back pain
1 finding from 1 review

Paracetamol vs placebo

Disability 1 week (immediate term) (RMDQ 0 to 24) · Patients with acute low‐back pain
1 finding from 1 review

NSAIDs vs placebo

Change in pain intensity from baseline on VAS (0 to 100) short‐term · people with low back pain with sciatica

It is very uncertain whether NSAIDs changes change in pain intensity from baseline on VAS (0 to 100) short‐term compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Short‐term maternal morbidity · women with term breech delivery

The intervention may leads to higher short‐term maternal morbidity (low certainty).

1 finding from 1 review