Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter‐related BSI as defined using criteria specified by Maki… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate‐related BSI as defined using criteria specified by O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate‐related BSI as defined using criteria specified by O'Grady… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate colonization any positive quantitative culture of infusate · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate colonization any positive quantitative culture of infusate compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter colonization any positive semiquantitative or quantitative… compared with more frequent (moderate certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in all‐cause BSI any positive blood culture drawn from a peripheral… compared with more frequent (low certainty).

1 finding from 1 review