Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,432 questions · 1,467 findings · 116 reviews · Headline outcomes only

No studies found 232 · 15.8%GRADE not reported 202 · 13.8%Very low 286 · 19.5%Low 327 · 22.3%Moderate 286 · 19.5%High 134 · 9.1%

Intervention not reported

4b. Persistent inconsolable crying8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine

It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying8 (very low certainty).

1 finding from 1 review

Intervention not reported

Severe local reaction11 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine
1 finding from 1 review

Intervention not reported

Non‐severe local reaction13 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine

The intervention showed no clear difference in non‐severe local reaction13 (low certainty).

1 finding from 1 review

Intervention not reported

Fever · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine
1 finding from 1 review

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Hospitalization · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of hospitalization compared with hospital intervention alone (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of ICU admission compared with hospital intervention alone (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

It is very uncertain whether MDAC + hospital intervention changes incidence of mortality compared with SDAC + hospital intervention (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to higher incidence of adverse events compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to lower incidence of ICU admission compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention (low certainty).

1 finding from 1 review