Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

INTENSIVE CASE MANAGEMENT vs usual care

Adverse event: 1b. Death ‐ suicide ‐ by long term · people with severe mental disorders

Intensive Case Management showed no clear difference in adverse event: 1b. Death ‐ suicide ‐ by long term compared with standard care (low certainty).

1 finding from 1 review

INTENSIVE CASE MANAGEMENT vs usual care

Social functioning: 2. Employment status (various measurements) ‐ by long term ‐ not employed at the end of the trial · people with severe mental disorders

It is very uncertain whether intensive Case Management changes social functioning: 2. Employment status (various measurements) ‐ by… compared with standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Smoking uptake at longest · Children and adolescents aged 5 ‐ 18 years who were non‐smokers at baseline

The intervention showed no clear difference in smoking uptake at longest (low certainty).

1 finding from 1 review

Intervention not reported

Smoking uptake at longest · Children and adolescents aged 5 ‐ 18 years who were non‐smokers at baseline

It is very uncertain whether the intervention changes smoking uptake at longest (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants who experienced prolonged vaginal discharge · Women undergoing excision of the cervical transformation zone for cervical neoplasia

The intervention showed no clear difference in number of participants who experienced prolonged vaginal discharge (low certainty).

1 finding from 1 review

Probiotics used as adjuvants to conventional antifungal drugs vs conventional antifungal drugs

Clinical cure · non‐pregnant women with vulvovaginal candidiasis

It is very uncertain whether probiotics used as adjuvants to conventional antifungal drugs changes clinical cure rate (long‐term) compared with conventional antifungal drugs (very low certainty).

1 finding from 1 review

Probiotics used as adjuvants to conventional antifungal drugs vs conventional antifungal drugs

Mycological cure · non‐pregnant women with vulvovaginal candidiasis

It is very uncertain whether probiotics used as adjuvants to conventional antifungal drugs changes mycological cure rate (long‐term) compared with conventional antifungal drugs (very low certainty).

1 finding from 1 review

One‐incision vs two‐incision techniques

Subjective function (long term) · adults undergoing arthroscopically assisted ACL reconstruction1

It is very uncertain whether one‐incision changes subjective function (long term) compared with two‐incision techniques (very low certainty).

1 finding from 1 review

Neuromuscular electrical stimulation + other intervention (e.g. exercise) vs other intervention alone

Knee pain (long term) VAS scale: 0 to 10; higher score = worse pain. · patients with patellofemoral pain syndrome (symptoms > 4 weeks (1 study); symptoms > 6 weeks (1 study); symptoms > 8 weeks (1 study); not…
1 finding from 1 review

Neuromuscular electrical stimulation + other intervention (e.g. exercise) vs other intervention alone

Kujala patellofemoral disorders score Scale from: 0 to 100 (higher scores = better function) · patients with patellofemoral pain syndrome (symptoms > 4 weeks (1 study); symptoms > 6 weeks (1 study); symptoms > 8 weeks (1 study); not…
1 finding from 1 review