Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste probably leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (moderate certainty).
1 finding from 1 review
SMD -0.08 [-0.14, -0.01]
10 studies
Moderate
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.23 [-0.5, 0.05]
Studies not reported
Low
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.2 [-0.46, 0.05]
Studies not reported
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
SMD -0.12 [-0.31, 0.07]
2 studies
Low
Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1 finding from 1 review
Interproximal caries · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.28 [-0.47, -0.09]
Studies not reported
Low
Unmet dental treatment need · Children aged 1-18 years
Narrative reports from 6 studies suggested greater unmet dental treatment need in children with learning disabilities (5 of 6 studies), but no quantitative data were available (certainty not graded).
1 finding from 1 review
Intervention not reported
Mean DMFT/dmft (caries severity) · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
The pooled mean DMFT/dmft (caries severity) was 5.7 (SD 3.6) across 5 studies; certainty not graded.
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 1450 to 1500 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD 0.05 [-0.19, 0.3]
Studies not reported
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.21 [-0.33, -0.1]
Studies not reported
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.16 [-0.35, 0.03]
1 study
Low
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste showed no clear difference in proportion developing new caries compared with 1000 to 1250 ppm F toothpaste (low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Adults with mature permanent dentition (aged 18 to 93 years at study start)
1000 or 1100 ppm F toothpaste probably leads to lower caries increment, surface index DMFS compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).
1 finding from 1 review
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
Interproximal caries · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Interproximal caries · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.24 [-0.44, -0.04]
Studies not reported
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.03 [-0.12, 0.06]
5 studies
Low